DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and Cse1

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_523588.2	Gene:	Cse1 / 35016	FlyBaseID:	FBgn0022213	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	1137	Identity:	243/1137 - (21%)
Similarity:	425/1137 - (37%)	Gaps:	289/1137 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 QKLTELLRATIDPNPEQRKAAE-----DQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLK 63
            |.|...|:.|:..:|..|:.||     .:|.|.:.|:     :|.::.:..::...|.|||:..|
  Fly     9 QLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPIL-----LLNLIDKAQMDMTTRVAGAIAFK 68

  Fly    64 NLINSSWSDHEAKPGEPIPFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRW 128
            |.|..:|:.|....|   |..|||.||..|:..||..::|:|..::.|||..|:.|.|.|||.:|
  Fly    69 NYIKRNWAAHLDSDG---PDRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKW 130

  Fly   129 PQVVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRLLAE 193
            ||::|.:.....:.|.|..||.|.|.:.|.|.|.|:...:  .|.|.:..:|..:.:.:..||..
  Fly   131 PQLIDEMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQ--ALWEEIKFVLDRMAKPLTDLLQA 193

  Fly   194 QSEQS-----------VLLQKQIL--KIYYALTQYTLPLDLITKEIF----SQWMEICRQVADRA 241
            ..:.:           |:....:|  |::::|....||      |.|    :.||....|.....
  Fly   194 TMQLTKVHENNAGALKVIYGSLVLVNKVFFSLNSQDLP------EFFEDNINTWMGAFIQQLAAD 252

  Fly   242 VPDSSHLDDDERTEFPYWKTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVL 306
            ||.....||::.....         |:..::.|.....:....|:::.|.|    .|...|.|:|
  Fly   253 VPSLRTADDEDAGVLE---------HLRAQVCENICLYAKKYDEEFKPFME----QFVTAVWELL 304

  Fly   307 LKILDQYRNRVYVSPRVLTDVLNYLKNAVSHAYTWKLI------------KPHMVAVIQD-VIFP 358
            :|                |.:.....:.||||..:..:            .|.::|.|.| |:.|
  Fly   305 VK----------------TSLHTKYDSLVSHALQFLSVVADRQHYQSIFENPEILAQICDKVVIP 353

  Fly   359 IMSFTDSDQELWESDPYEYIRLKFDIFEDYATPVPAAQSLLHSMC----KKRKGILPKAMATIM- 418
            .:....||:|::|..|.||||...: ..|..|...||..|:.::.    :|..||..:.:..::
  Fly   354 NLDIRPSDEEIFEDSPEEYIRRDIE-GSDIDTRRRAACDLVKTLSINFEQKIFGIFGQYLERLLT 417

  Fly   419 QIITSPNADNKQKDGALHMI------GTLADVLLKKASYRDQVESMLTTYVFPEFQNPAGH---- 473
            :...:|..:.:.||.|::::      |......:.:.|....:.......:.||.:.|..:
  Fly   418 KYKENPATNWRSKDTAIYLVTSWASRGGTQKHGITQTSELVPLPEFCAQQIIPELERPNINEFPV 482

  Fly   474 MRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVEAAIGLQMFISSQDEA----- 533
            ::|.|...:..|  ..|..|||||..:......|..:..: |...||..::..:|.:|.:
  Fly   483 LKAAAIKYVMVF--RSILGPQVLASCLPQLIRHLPAESSV-VHSYAACSVEKILSMRDASNAIVF 544

  Fly   534 -PQYVEAQIKEITKEL---LTIIRETENEDLTNVMQKIVCTFTEQLLPVATEICQHLATTFSQVL 594
             ||.:.....|:...|   |::....|||   .||:.|:.:|:         :.|..|..|..|
  Fly   545 GPQILAPYTTELISGLFATLSLPGSGENE---YVMKAIMRSFS---------VLQSAAMPFMGV- 596

  Fly   595 ESEEGSDEKAITAMSLLNTIETLLSVMEEHPD---VLLNLHPIVINVVGHIFQHNITDFYEETFS 656
                        |:..|..|.|.::.....|.   .|.....:.|.:|.|.....::.|.|..|.
  Fly   597 ------------ALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEEALFP 649

  Fly   657 LVYDLTAKAI---SPEMWQMLELIYQVFKKDGIDYFID---------IMPALHNYVTVDTP---- 705
            :...:..:.|   .|.::|||.::.::  ::|.....:         :.|||.:.....||
  Fly   650 VFQGILQQDIVEFMPYVFQMLSVLLEM--REGTGTIPEPYWALFPCLLSPALWDRTGNVTPLIRL 712

  Fly   706 --AFLSNPN-------RLLAILDMCKTMLTSSPGEDPECHAAKLMEVIILQCKGQIDSVIH---- 757
              ||:...:       :|..||.:.:.|:.|...:....:.  |..::......:|.:.:.
  Fly   713 ISAFIKQGSAQIQALGKLSGILGIFQKMIASKANDHEGFYL--LQNLLSYYPPAEIQTNLRQIFG 775

  Fly   758 -MFVELALSRLTREVQSSELRTMCLQVVIAALYY----------------NPQLLLSILDKMSQQ 805
             :|..|:||:..:.:..         ::|...:|                .|.|...:||::
  Fly   776 LLFQRLSLSKTPKYLSG---------IIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRV--- 828

  Fly   806 NNDSISAHFIKQWLHDTDCFLG----IHDRKLCVLGLCTLISLGEAKPQVLSEVAG----KIVPA 862
                    ||.:        :|    ..|||:..:|:..|::   ..|::|.:...    :::.:
  Fly   829 --------FITE--------MGKIPKEQDRKMVAVGVTKLLT---ETPEILQQQYATFWPRLLHS 874

  Fly   863 LILLFDGLKRAYESRAQEEEEDEEEEDGDDCEEALSSDEDDMDEMAPD--YLDKLAEFAKTKGNE 925
            ||.||              |...|:..|.:..|.....||      ||  |....|:....:.|:
  Fly   875 LIDLF--------------ERPPEKLMGLEIGETAGVAED------PDAGYQVAFAQLTHAQPNQ 919

  Fly   926 SGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDDEENESAIDEYWTFKEVITALSAQD 990
            .  :..||||        ||.:.:.    |.|..|                           ||.
  Fly   920 Q--DHLAEIK--------DARQFLA----TSLSKF---------------------------AQA 943

  Fly   991 QAW-YALLTSNLTPEQAKALQEVVVTADQRKA 1021
            :|. ::.|.|.|.||..:.||:....|..|.|
  Fly   944 RAGEFSTLLSPLEPEYKQVLQKYCDQAGVRIA 975

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	240/1127 (21%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761	25/83 (30%)
Cse1	NP_523588.2	IBN_N	29..105	CDD:281761	25/83 (30%)
		Cse1	159..528	CDD:285678	84/409 (21%)
		CAS_CSE1	530..966	CDD:281384	104/556 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45446876
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10997
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940