DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and ipo7

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_957199.2	Gene:	ipo7 / 321739	ZFINID:	ZDB-GENE-030131-458	Length:	1039	Species:	Danio rerio

Alignment Length:	1057	Identity:	552/1057 - (52%)
Similarity:	756/1057 - (71%)	Gaps:	34/1057 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAQKLTELLRATIDPNPEQRKAAEDQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLKNL 65
            |:...|.|.||.|:|.|  .|:|||.||.:.|..:.|:.|:||:.|...::.||||||.:||||:
Zfish     1 MDLNTLIEALRGTMDAN--LREAAERQLNEGHSQVNFMSTLLQLTMTEQLDLPVRQAGVIYLKNM 63

  Fly    66 INSSWSDHEAKPGEPIPFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRWPQ 130
            :...|::.:....|....:|.|.||..||..||:||:.:||.|||||:.|::|:||.|:||||..
Zfish    64 VTQFWTEGDNANTEAPTSTIPETDRQFIRDNIVEAIIQSPERIRVQLTTCIHHMIKHDYPGRWTA 128

  Fly   131 VVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRLLAEQS 195
            :||.|.:|||:.:.:.|.|.|:.:|||||.||||:.|||.||..||.:.:||:....::||.:.|
Zfish   129 IVDKIGLYLQSDNSSYWLGILLCLYQLVKNYEYKKPEERQPLVAAMQIFMPMLKDRFIQLLPDTS 193

  Fly   196 EQSVLLQKQILKIYYALTQYTLPLDLITKEIFSQWMEICRQVADRAVP-DSSHLDDDERTEFPYW 259
            ..|||:|||||||.|||.||.|||:||.::..::||||.:.|.||.|| ::..:|:|||.|.|:|
Zfish   194 ADSVLVQKQILKILYALFQYNLPLELINRQNLTEWMEILKTVVDRDVPQETLQVDEDERPELPWW 258

  Fly   260 KTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVLLKILDQYRNRVYVSPRVL 324
            |.|||||||:.|:|||||||.|...| |.:|||.:|..::....:||||:|.||:.:.||:||||
Zfish   259 KCKKWALHILARLFERYGSPGNTTKE-YTEFAELFLKGYAVAAQQVLLKVLYQYKEKQYVAPRVL 322

  Fly   325 TDVLNYLKNAVSHAYTWKLIKPHMVAVIQDVIFPIMSFTDSDQELWESDPYEYIRLKFDIFEDYA 389
            ...|||:...::||.|||.:|||:..::|||:||:|.:||||:|||:.|||||||:|||:|||:.
Zfish   323 QQTLNYINQGIAHAVTWKNLKPHIQGIVQDVVFPLMCYTDSDEELWQEDPYEYIRMKFDVFEDFI 387

  Fly   390 TPVPAAQSLLHSMCKKRKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKASYRDQ 454
            :|..|||:||.:.|.|||.:|.|:|....||:|.|..|.::|||||||||:||::|||:..|:||
Zfish   388 SPATAAQTLLFTACNKRKEVLQKSMGFCYQILTDPATDPRKKDGALHMIGSLAEILLKRKIYKDQ 452

  Fly   455 VESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVEA 519
            :|.||..:|||.|::..|:|||||||||||||:|:.||.|.|...:.||.|.|:.|.||||||||
Zfish   453 MEFMLQNHVFPLFRSELGYMRARACWVLHYFCEVKFKNDQNLQVALELTRNCLINDNELPVKVEA 517

  Fly   520 AIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQLLPVATEICQ 584
            ||.||:.:|:|::|..|:...|:.:.:.||.|:|||||:|||||:||::|.::|::.|:|.|:.|
Zfish   518 AIALQVLVSNQEKAKDYITPHIRPVMQALLQIVRETENDDLTNVIQKMICEYSEEVTPIAVEMTQ 582

  Fly   585 HLATTFSQVLES---EEGSDEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHIFQHN 646
            |||.||:||:::   |||.|:||:|||.:||||:|||||:|:|.::...|..|.:.|:|.:.|.:
Zfish   583 HLAMTFNQVIQTGPDEEGGDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQH 647

  Fly   647 ITDFYEETFSLVYDLTAKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTVDTPAFLSNP 711
            :.:||||..||.:.||.:.:||:|||:|.|||.||::||.|||.|:||.||||:||||...||:.
Zfish   648 VLEFYEEILSLAHSLTCQQVSPQMWQLLPLIYDVFQQDGFDYFTDMMPLLHNYITVDTDTLLSDT 712

  Fly   712 NRLLAILDMCKTMLTSSPGEDPECHAAKLMEVIILQCKGQ-IDSVIHMFVELALSRLTREVQSSE 775
            ..|..|.:|||.:||..||||||||||||:|||||||||: ||.|:.:||..||.||||||::||
Zfish   713 KYLEIIYNMCKKILTGDPGEDPECHAAKLLEVIILQCKGRGIDQVVPLFVTTALERLTREVKTSE 777

  Fly   776 LRTMCLQVVIAALYYNPQLLLSILDKMSQQNN-DSISAHFIKQWLHDTDCFLGIHDRKLCVLGLC 839
            ||||||||.|||:||:|.|||:.|:.:...|| :.|:.|||.|||.|.|||||:||||:||||||
Zfish   778 LRTMCLQVAIAAIYYSPPLLLNTLENLRFPNNTEPITNHFISQWLKDIDCFLGLHDRKMCVLGLC 842

  Fly   840 TLISLGEAKPQVLSEVAGKIVPALILLFDGLKRAYESRAQ-EEEEDEEEEDGDDCEE--ALSSDE 901
            .|:.| |.:||.:::|||:::||.||||:||||||..||: |.:||::||||::.||  .|.|||
Zfish   843 ALMDL-EQRPQAVNQVAGQLLPAAILLFNGLKRAYACRAEHENDEDDDEEDGEEEEENAELGSDE 906

  Fly   902 DDMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDD 966
            ||:|:...:||:.||:.|...|::..:|      :|||:             ||.||.:||.:||
Zfish   907 DDIDDEGQEYLEMLAKQAGEDGDDEDWE------EDDAE-------------ETALEGYTTLVDD 952

  Fly   967 EENESAIDEYWTFKEVITALSAQDQAWYALLTSNLTPEQAKALQEVVVTADQRKAAKESKLIEKQ 1031
            |:|  .:|||..||.::..:.|:|.|||..:|..|..||.|.||::...||||:||.|||:|||.
Zfish   953 EDN--LVDEYQIFKAIMQNVQARDPAWYQAITHCLDEEQRKQLQDIATLADQRRAAHESKMIEKH 1015

  Fly  1032 GGFAFPQTAVPTSFKFG 1048
            ||:.|....||:||.||
Zfish  1016 GGYKFTAPVVPSSFNFG 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	530/1017 (52%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761	32/78 (41%)
ipo7	NP_957199.2	SXM1	15..998	CDD:227943	525/1007 (52%)
ipo7	NP_957199.2	IBN_N	22..101	CDD:281761	32/78 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595413
Domainoid	1	1.000	649	1.000	Domainoid score	I154
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4659
Inparanoid	1	1.050	1112	1.000	Inparanoid score	I219
OMA	1	1.010	-	-		QHG53555
OrthoDB	1	1.010	-	-		D159062at2759
OrthoFinder	1	1.000	-	-		FOG0002119
OrthoInspector	1	1.000	-	-		otm24495
orthoMCL	1	0.900	-	-		OOG6_101190
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R599
SonicParanoid	1	1.000	-	-		X1573
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800