DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and Skiv2l

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	XP_006255985.1	Gene:	Skiv2l / 294260	RGDID:	1303059	Length:	1244	Species:	Rattus norvegicus

Alignment Length:	923	Identity:	179/923 - (19%)
Similarity:	306/923 - (33%)	Gaps:	285/923 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   220 DLITKEIFS--------------QW---MEICRQVAD--RAVPDSS----------------HLD 249
            ||:.||..:              ||   :::...|.|  |.:|..:                ||:
  Rat   256 DLVLKEASTVVSTLEPLKPPPQEQWAVPVDVTSPVGDFYRLIPQPAFQWAFEPDVFQKQAILHLE 320

  Fly   250 DDE------RTEFPYWKTKKWALHIMVRMFER--YGSPSNVVSEKYQKFAEWYLPTFSQ-GVL-- 303
            ..:      .|........::|:.:..:...|  |.||...:|.  |||.: :..||.. |:|
  Rat   321 QHDSVFVAAHTSAGKTVVAEYAIALAQKHMTRTIYTSPIKALSN--QKFRD-FRNTFGDVGLLTG 382

  Fly   304 --------EVLLKILDQYRNRVYVSPRVLTDV-------LNYLKNAVSHAYTWK----LIKPHMV 349
                    ..|:...:..|:.:|....|:.|:       ::|:.:| .....|:    ::..|:.
  Rat   383 DVQLHPEASCLIMTTEILRSMLYSGSDVIRDLEWVIFDEVHYINDA-ERGVVWEEVLIMLPEHVS 446

  Fly   350 AVIQDVIFP-IMSFTDSDQELWESDPYEYIRLK---FDIFEDYATPVPAAQSLLHSMCKKRKGIL 410
            .::.....| .:.|.|     |..      |||   ..:....|.|||....|.       .|..
  Rat   447 IILLSATVPNALEFAD-----WIG------RLKRRQIYVISTVARPVPLEHYLF-------TGNS 493

  Fly   411 PKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKASYRDQVESMLTTYVFPEFQNPAGHMR 475
            ||....:..::.|        .||.|..|..|.|..||    :::.....|:...:..:..|..:
  Rat   494 PKTQGELFLLLDS--------RGAFHTKGYYAAVEAKK----ERMSKHAQTFGAKQPTHQGGPAQ 546

  Fly   476 ARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVEAAIGLQMFISSQDEAPQYVEAQ 540
            .|..:               ||.:..|.|.|     :|||.|        |..|:....:....
  Rat   547 DRGVY---------------LALLASLRTRA-----QLPVVV--------FTFSRGRCDEQASG- 582

  Fly   541 IKEITKELLTIIRETENEDLTNVMQKIVCTFTEQLLPVATEICQHLATTFSQVLESEEGSDEKAI 605
                    ||.:      |||...:|             :||  ||  ...:.|....|||.:..
  Rat   583 --------LTSL------DLTTSSEK-------------SEI--HL--FLQRCLARLRGSDRQLP 616

  Fly   606 TAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHIFQHNITD--FYEETFSLVYDLTAKAISP 668
            ..:.:...:...|.|  .|..:|    ||:..:|..:|...:..  |..|||::..::.|:.:
  Rat   617 QVLHMSELLRRGLGV--HHSGIL----PILKEIVEMLFSRGLVKVLFATETFAMGVNMPARTV-- 673

  Fly   669 EMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTVDTPAFLSNPNRLLAILDMCKTMLTSSPGEDP 733
                    ::...:|.....|.|::|.  .||.:...|                    ...|.||
  Rat   674 --------VFDSMRKHDGSTFRDLLPG--EYVQMAGRA--------------------GRRGLDP 708

  Fly   734 ECHAAKLMEVIILQCKGQIDSV--IHMFVELALSRLTREVQSSELR---TMCLQVV-IAALYYNP 792
                   ...:||.|||::..:  :|..:....|:|     .|:.|   ||.|.:: :.||....
  Rat   709 -------TGTVILLCKGRVPEMADLHRMMMGKPSQL-----QSQFRLTYTMILNLLRVDALRVED 761

  Fly   793 QLLLSILDKMSQQNNDSISAHFIKQWLHDTDCFLGIHDRKLCVLGLCTLISLGE--AKPQVLSEV 855
            .:..|..:..|::::   .||  :|.|.|....||..:.. .|.|  .|..|.|  :..:.|:|.
  Rat   762 MMKRSFSEFPSRKDS---KAH--EQALADLTKRLGALEEP-DVTG--QLADLPEYYSWAEELTET 818

  Fly   856 AGKIVPALILLFDGLKRAYESRAQEEEEDEE--------EEDGDD----------CEE-ALSSDE 901
            ...|...::...:|||.....|....:.:|.        :...:.          |:: |:|.:.
  Rat   819 RNMIQRRIMESVNGLKSLSVGRVVVVKNEEHHNALGVILQVSSNSTSRVFTTLVLCDKPAVSENP 883

  Fly   902 DDMDEMAPD--YLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPI 964
            .|.....||  :.|.|.          ||::..        .:|..|.:|..|....:.:.:|.:
  Rat   884 RDKGPATPDVPHPDDLV----------GFKLFL--------PEGPCEHTVAKLQPGDVAAISTKV 930

  Fly   965 DDEENESAIDEYWTFKE-----------VITA---LSAQDQAWYALLTSNLTPEQAKALQEVVVT 1015
            .....|...:::...::           |.||   |....|| |......|.|.....|::|.|.
  Rat   931 LRVNGEKISEDFSKRQQPKFRKDPPLAAVTTAVQELLRLAQA-YPAGPPTLDPINDLQLKDVAVV 994

  Fly  1016 ADQRKAAKESKLI 1028
            ....:|.|..:||
  Rat   995 EGGLRARKLEELI 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	173/906 (19%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761
Skiv2l	XP_006255985.1	TMEM51	<219..277	CDD:291990	4/20 (20%)
		Dob10	288..1242	CDD:226947	173/891 (19%)
		DEAD	312..459	CDD:278688	26/150 (17%)
		HELICc	621..705	CDD:197757	20/121 (17%)
		rRNA_proc-arch	762..1040	CDD:289976	54/273 (20%)
		DSHCT	1070..1236	CDD:285374
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900