DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and Ipo7

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_852658.2	Gene:	Ipo7 / 233726	MGIID:	2152414	Length:	1038	Species:	Mus musculus

Alignment Length:	1057	Identity:	568/1057 - (53%)
Similarity:	767/1057 - (72%)	Gaps:	35/1057 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAQKLTELLRATIDPNPEQRKAAEDQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLKNL 65
            |:...:.|.||.|:|  |..|:|||.||.:.||.:.||.|:|||.|...::.||||||.:||||:
Mouse     1 MDPNTIIEALRGTMD--PALREAAERQLNEAHKSLNFVSTLLQITMSEQLDLPVRQAGVIYLKNM 63

  Fly    66 INSSWSDHEAKPGEPIPFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRWPQ 130
            |...|.|.||.||:..|::|.|:||..||..||:||:|:||||||||:.|::||||.|:|.||..
Mouse    64 ITQYWPDREATPGDIAPYTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPSRWTA 128

  Fly   131 VVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRLLAEQS 195
            :||.|..|||:.:...|.|.|:.:|||||.||||:.|||:||..||...||::....::||::||
Mouse   129 IVDKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLVAAMQHFLPVLKDRFIQLLSDQS 193

  Fly   196 EQSVLLQKQILKIYYALTQYTLPLDLITKEIFSQWMEICRQVADRAVPDSS-HLDDDERTEFPYW 259
            :||||:||||.||:|||.||||||:||.::..::|:||.:.|.:|.||:.: .:::|:|.|.|:|
Mouse   194 DQSVLIQKQIFKIFYALVQYTLPLELINQQNLTEWVEILKTVVNRDVPNETLQVEEDDRPELPWW 258

  Fly   260 KTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVLLKILDQYRNRVYVSPRVL 324
            |.|||||||:.|:|||||||.| ||::|.:|||.:|..|:.||.:||||:|.||:.:.|::||||
Mouse   259 KCKKWALHILARLFERYGSPGN-VSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYMAPRVL 322

  Fly   325 TDVLNYLKNAVSHAYTWKLIKPHMVAVIQDVIFPIMSFTDSDQELWESDPYEYIRLKFDIFEDYA 389
            ...|||:...||||.|||.:|||:..:|||||||:|.:||:|:|||:.|||||||:|||:|||:.
Mouse   323 QQTLNYINQGVSHALTWKNLKPHIQGIIQDVIFPLMCYTDADEELWQEDPYEYIRMKFDVFEDFI 387

  Fly   390 TPVPAAQSLLHSMCKKRKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKASYRDQ 454
            :|..|||:||.:.|.|||.:|.|.|....||:|.||||.::|||||||||:||::||||..|:||
Mouse   388 SPTTAAQTLLFTACSKRKEVLQKTMGFCYQILTEPNADPRKKDGALHMIGSLAEILLKKKIYKDQ 452

  Fly   455 VESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVEA 519
            :|.||..:|||.|.:..|:|||||||||||||:|:.|:.|.|...:.||...|:.|:|:||||||
Mouse   453 MEYMLQNHVFPLFSSELGYMRARACWVLHYFCEVKFKSDQNLQTALELTRRCLIDDREMPVKVEA 517

  Fly   520 AIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQLLPVATEICQ 584
            ||.||:.||:|::|.:|:...|:.:.:.||.|||||||:|||||:||::|.::|::.|:|.|:.|
Mouse   518 AIALQVLISNQEKAKEYITPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQ 582

  Fly   585 HLATTFSQVLES---EEGSDEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHIFQHN 646
            |||.||:||:::   |||||:||:|||.:||||:|||||:|:|.::...|..|.:.|:|.:.|.:
Mouse   583 HLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQH 647

  Fly   647 ITDFYEETFSLVYDLTAKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTVDTPAFLSNP 711
            :.:||||.|||.:.||.:.:||:|||:|.|:::||::||.|||.|:||.|||||||||...||:.
Mouse   648 VLEFYEEIFSLAHSLTCQQVSPQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLLSDT 712

  Fly   712 NRLLAILDMCKTMLTSSPGEDPECHAAKLMEVIILQCKGQ-IDSVIHMFVELALSRLTREVQSSE 775
            ..|..|..|||.:||...|||.|||||||:|||||||||: ||..|.:|||.||.||||||::||
Mouse   713 KYLEMIYSMCKKVLTGVAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVEAALERLTREVKTSE 777

  Fly   776 LRTMCLQVVIAALYYNPQLLLSILDKMSQQNN-DSISAHFIKQWLHDTDCFLGIHDRKLCVLGLC 839
            ||||||||.||||||||.|||:.|:.:...|| :.::.|||.|||:|.|||||:||||:||||||
Mouse   778 LRTMCLQVAIAALYYNPHLLLNTLENLRFPNNVEPVTNHFITQWLNDVDCFLGLHDRKMCVLGLC 842

  Fly   840 TLISLGEAKPQVLSEVAGKIVPALILLFDGLKRAYESRAQEE---EEDEEEEDGDDCEEALSSDE 901
            .||.: |..||||::|:|:|:||.||||:||||||...|:.|   ::||:.||.|:.|| |.|||
Mouse   843 ALIDM-EQIPQVLNQVSGQILPAFILLFNGLKRAYACHAEHENDSDDDEDAEDDDETEE-LGSDE 905

  Fly   902 DDMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDD 966
            ||:||...:||:.||:.|...|::..:|      :|||:             ||.||.::|.|||
Mouse   906 DDIDEDGQEYLEILAKQAGEDGDDEDWE------EDDAE-------------ETALEGYSTIIDD 951

  Fly   967 EENESAIDEYWTFKEVITALSAQDQAWYALLTSNLTPEQAKALQEVVVTADQRKAAKESKLIEKQ 1031
            |:|  .:|||..||.:...:..::..||..||..|..||.|.||::...||||:||.|||:|||.
Mouse   952 EDN--PVDEYQIFKAIFQTIQNRNPVWYQALTHGLNEEQRKQLQDIATLADQRRAAHESKMIEKH 1014

  Fly  1032 GGFAFPQTAVPTSFKFG 1048
            ||:.|....||:||.||
Mouse  1015 GGYKFSAPVVPSSFNFG 1031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	546/1017 (54%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761	41/78 (53%)
Ipo7	NP_852658.2	SXM1	15..997	CDD:227943	542/1007 (54%)
		IBN_N	22..101	CDD:281761	41/78 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	881..910		14/29 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849656
Domainoid	1	1.000	639	1.000	Domainoid score	I167
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4659
Inparanoid	1	1.050	1142	1.000	Inparanoid score	I214
Isobase	1	0.950	-	0	Normalized mean entropy	S2839
OMA	1	1.010	-	-		QHG53555
OrthoDB	1	1.010	-	-		D159062at2759
OrthoFinder	1	1.000	-	-		FOG0002119
OrthoInspector	1	1.000	-	-		otm42551
orthoMCL	1	0.900	-	-		OOG6_101190
Panther	1	1.100	-	-	LDO	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R599
SonicParanoid	1	1.000	-	-		X1573
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	17.750