DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and IPO8

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	NP_006381.2	Gene:	IPO8 / 10526	HGNCID:	9853	Length:	1037	Species:	Homo sapiens

Alignment Length:	1058	Identity:	515/1058 - (48%)
Similarity:	726/1058 - (68%)	Gaps:	35/1058 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAQKLTELLRATIDPNPEQRKAAEDQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLKNL 65
            |:..::.:.|:.|||  |:.|.|||::|.|.:|||.|.|::|:|::...||.|||||.|:||||:
Human     1 MDLNRIIQALKGTID--PKLRIAAENELNQSYKIINFAPSLLRIIVSDHVEFPVRQAAAIYLKNM 63

  Fly    66 INSSWSDHEAKPGEPI-PFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRWP 129
            :...|.|.|..|||.| ||:|||.||..||..||:.|:.:|:|:||||::|:..|||.||||.||
Human    64 VTQYWPDREPPPGEAIFPFNIHENDRQQIRDNIVEGIIRSPDLVRVQLTMCLRAIIKHDFPGHWP 128

  Fly   130 QVVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRLLAEQ 194
            .|||.|..|||:|....|.|:|:.:||||||||||:.|||.||..||.:.||.|.|.:|:||.:.
Human   129 GVVDKIDYYLQSQSSASWLGSLLCLYQLVKTYEYKKAEEREPLIIAMQIFLPRIQQQIVQLLPDS 193

  Fly   195 SEQSVLLQKQILKIYYALTQYTLPLDLITKEIFSQWMEICRQVADRAV-PDSSHLDDDERTEFPY 258
            |..|||||||||||:|||.||.|||.|:..:..:.||||.|.:.||.| |::.|:|:|:|.|..:
Human   194 SYYSVLLQKQILKIFYALVQYALPLQLVNNQTMTTWMEIFRTIIDRTVPPETLHIDEDDRPELVW 258

  Fly   259 WKTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVLLKILDQYRNRVYVSPRV 323
            ||.|||||||:.|:|||||||.||..| |.:|:|::|.|::.|:.:||||||||||.:.||:|||
Human   259 WKCKKWALHIVARLFERYGSPGNVTKE-YFEFSEFFLKTYAVGIQQVLLKILDQYRQKEYVAPRV 322

  Fly   324 LTDVLNYLKNAVSHAYTWKLIKPHMVAVIQDVIFPIMSFTDSDQELWESDPYEYIRLKFDIFEDY 388
            |....|||...|.|:.|||.:|||:..:.:||||.:|.:.|.|:|||:.|||||||:||||||||
Human   323 LQQAFNYLNQGVVHSITWKQMKPHIQNISEDVIFSVMCYKDEDEELWQEDPYEYIRMKFDIFEDY 387

  Fly   389 ATPVPAAQSLLHSMCKKRKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKASYRD 453
            |:|..|||:||::..||||.:|||.||...||:|.||.|.::||||||:||:||::||||:.::|
Human   388 ASPTTAAQTLLYTAAKKRKEVLPKMMAFCYQILTDPNFDPRKKDGALHVIGSLAEILLKKSLFKD 452

  Fly   454 QVESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVE 518
            |:|..|..:|||...:..|::|||:|||||.|..::..|...|...:.|...:|:.|||:|||||
Human   453 QMELFLQNHVFPLLLSNLGYLRARSCWVLHAFSSLKFHNELNLRNAVELAKKSLIEDKEMPVKVE 517

  Fly   519 AAIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQLLPVATEIC 583
            ||:.||..||:|.:|.:|::..::.|.:|||.|:|||||:|:|||:||::|.:::::..:|.::.
Human   518 AALALQSLISNQIQAKEYMKPHVRPIMQELLHIVRETENDDVTNVIQKMICEYSQEVASIAVDMT 582

  Fly   584 QHLATTFSQVLESEEGS--DEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHIFQHN 646
            ||||..|.:||:|:|..  ::|.:.||.:|:||:|:|:|:|:|.::...|..|.:.::..:.|.:
Human   583 QHLAEIFGKVLQSDEYEEVEDKTVMAMGILHTIDTILTVVEDHKEITQQLENICLRIIDLVLQKH 647

  Fly   647 ITDFYEETFSLVYDLTAKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTVDTPAFLSNP 711
            :.:||||..||.|.||..:|||:|||:|.::|:||::|..:||.|:||.||||||:||...|||.
Human   648 VIEFYEEILSLAYSLTCHSISPQMWQLLGILYEVFQQDCFEYFTDMMPLLHNYVTIDTDTLLSNA 712

  Fly   712 NRLLAILDMCKTMLTSSPGEDPECHAAKLMEVIILQCKGQ-IDSVIHMFVELALSRLTREVQSSE 775
            ..|..:..||:.:|....|||.|||||||:|||||||||: ||..|.:||:|.|.||||.|::||
Human   713 KHLEILFTMCRKVLCGDAGEDAECHAAKLLEVIILQCKGRGIDQCIPLFVQLVLERLTRGVKTSE 777

  Fly   776 LRTMCLQVVIAALYYNPQLLLSILDKMSQQNNDS-ISAHFIKQWLHDTDCFLGIHDRKLCVLGLC 839
            ||||||||.||||||||.|||..|:::...:|.. |:..||.||::|||||||.||||:|::||.
Human   778 LRTMCLQVAIAALYYNPDLLLHTLERIQLPHNPGPITVQFINQWMNDTDCFLGHHDRKMCIIGLS 842

  Fly   840 TLISLGEAKPQVLSEVAGKIVPALILLFDGLKRAYESRAQEEEEDEEEEDGDDCE--EALSSDED 902
            .|:.| :.:|..:..|.|:|||:::.||.|||:...:|.....||..:.:..|.|  |.:||||:
Human   843 ILLEL-QNRPPAVDAVVGQIVPSILFLFLGLKQVCATRQLVNREDRSKAEKADMEENEEISSDEE 906

  Fly   903 DMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDDE 967
            :.:..|.         |....|..|        :|:.:.|.|.:|.|  |.||.||.|:||:|
Human   907 ETNVTAQ---------AMQSNNGRG--------EDEEEEDDDWDEEV--LEETALEGFSTPLD-- 950

  Fly   968 ENESAIDEYWTFKEVITALSAQDQAWYALLTSNLTPEQAKALQEVVVTADQRKAAKES-KLIEKQ 1031
             .::::|||..|.:.:..:.::|.|||.||.:.|:.:|..|||||...|:.|:...|: |.||:|
Human   951 -LDNSVDEYQFFTQALITVQSRDAAWYQLLMAPLSEDQRTALQEVYTLAEHRRTVAEAKKKIEQQ 1014

  Fly  1032 GGFAFPQTAVPTSFKFGS 1049
            |||.|....|.::|.||:
Human  1015 GGFTFENKGVLSAFNFGT 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	498/1016 (49%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761	42/79 (53%)
IPO8	NP_006381.2	SXM1	15..996	CDD:227943	496/1006 (49%)
		IBN_N	22..101	CDD:281761	41/78 (53%)
		CAS_CSE1	<741..>869	CDD:281384	72/128 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	886..934		15/64 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	639	1.000	Domainoid score	I164
eggNOG	1	0.900	-	-		E1_COG4581
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1140	1.000	Inparanoid score	I216
Isobase	1	0.950	-	0	Normalized mean entropy	S2839
OMA	1	1.010	-	-		QHG53555
OrthoDB	1	1.010	-	-		D159062at2759
OrthoFinder	1	1.000	-	-		FOG0002119
OrthoInspector	1	1.000	-	-		otm40474
orthoMCL	1	0.900	-	-		OOG6_101190
Panther	1	1.100	-	-	O	PTHR10997
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R599
SonicParanoid	1	1.000	-	-		X1573
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820