DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment msk and ipo7

DIOPT Version :9

Sequence 1:	NP_524780.1	Gene:	msk / 44747	FlyBaseID:	FBgn0026252	Length:	1049	Species:	Drosophila melanogaster
Sequence 2:	XP_012815848.1	Gene:	ipo7 / 100101664	XenbaseID:	XB-GENE-919773	Length:	1038	Species:	Xenopus tropicalis

Alignment Length:	1057	Identity:	571/1057 - (54%)
Similarity:	766/1057 - (72%)	Gaps:	33/1057 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MEAQKLTELLRATIDPNPEQRKAAEDQLAQIHKIIGFVPTILQIVMQTTVEQPVRQAGAVYLKNL 65
            |:...|.|.||.|:|  |..|:|||.||.:.||.:.||.|:|||.|...::.||||||.:||||:
Frog     1 MDPNILIEALRGTMD--PALREAAERQLNESHKSLHFVSTLLQITMSEQLDLPVRQAGVIYLKNM 63

  Fly    66 INSSWSDHEAKPGEPIPFSIHEQDRAMIRGAIVDAIVHAPELIRVQLSVCVNHIIKSDFPGRWPQ 130
            |...|.|.|..|||..|.:|.|:||..||..||:||:|:||||||||:.|::||||.|:|.||..
Frog    64 ITQYWPDREVTPGELPPHTIPEEDRHCIRENIVEAIIHSPELIRVQLTTCIHHIIKHDYPNRWTA 128

  Fly   131 VVDSISIYLQNQDVNGWNGALVTMYQLVKTYEYKRHEERTPLNEAMNLLLPMIYQLMVRLLAEQS 195
            ||:.|..|||:.:...|.|.|:.:|||||.||||:.|||:||..||...|||:....::|||:.|
Frog   129 VVEKIGFYLQSDNSACWLGILLCLYQLVKNYEYKKPEERSPLIAAMQHFLPMLKDRYIQLLADPS 193

  Fly   196 EQSVLLQKQILKIYYALTQYTLPLDLITKEIFSQWMEICRQVADRAVP-DSSHLDDDERTEFPYW 259
            |||||:||||.||:|||.||||||:||.::..::|:||.:.|.||.|| ::..:|:|:|.|.|:|
Frog   194 EQSVLIQKQIFKIFYALVQYTLPLELINQQNLAEWIEILKTVVDRDVPAETLQVDEDDRPELPWW 258

  Fly   260 KTKKWALHIMVRMFERYGSPSNVVSEKYQKFAEWYLPTFSQGVLEVLLKILDQYRNRVYVSPRVL 324
            |.|||||||:.|:|||||||.| ||::|.:|||.:|..|:.||.:||||:|.||:.:.|::||||
Frog   259 KCKKWALHILARLFERYGSPGN-VSKEYNEFAEVFLKAFAVGVQQVLLKVLYQYKEKQYIAPRVL 322

  Fly   325 TDVLNYLKNAVSHAYTWKLIKPHMVAVIQDVIFPIMSFTDSDQELWESDPYEYIRLKFDIFEDYA 389
            ...||||...||||.|||.:|||:..:|||||||:|.:||||:|||:.|||||||:|||:|||:.
Frog   323 QQTLNYLNQGVSHAMTWKNLKPHIQGIIQDVIFPLMCYTDSDEELWQEDPYEYIRMKFDVFEDFI 387

  Fly   390 TPVPAAQSLLHSMCKKRKGILPKAMATIMQIITSPNADNKQKDGALHMIGTLADVLLKKASYRDQ 454
            :|..|||:||.:.|.|||.:|.|.|....||:|.|.||.::|||||||||:||::||||..|:||
Frog   388 SPTTAAQTLLFTSCSKRKEVLQKTMGFCYQILTEPAADPRKKDGALHMIGSLAEILLKKKIYKDQ 452

  Fly   455 VESMLTTYVFPEFQNPAGHMRARACWVLHYFCDVQIKNPQVLAEIMRLTTNALLTDKELPVKVEA 519
            :|.||..:||..|.:..|:|||||||||||||:|:.|..|.|...:.||...|:.|:|:||||||
Frog   453 MEFMLQNHVFTLFSSELGYMRARACWVLHYFCEVKFKIDQNLQTALELTRRCLIDDREMPVKVEA 517

  Fly   520 AIGLQMFISSQDEAPQYVEAQIKEITKELLTIIRETENEDLTNVMQKIVCTFTEQLLPVATEICQ 584
            ||.||:.||:|::|.:|:...|:.:.:.||.|||||||:|||||:||::|.::|::.|:|.|:.|
Frog   518 AIALQVLISNQEKAKEYIAPFIRPVMQALLHIIRETENDDLTNVIQKMICEYSEEVTPIAVEMTQ 582

  Fly   585 HLATTFSQVLES---EEGSDEKAITAMSLLNTIETLLSVMEEHPDVLLNLHPIVINVVGHIFQHN 646
            |||.||:||:::   |||||:||:|||.:||||:|||||:|:|.::...|..|.:.|:|.:.|.:
Frog   583 HLAMTFNQVIQTGPDEEGSDDKAVTAMGILNTIDTLLSVVEDHKEITQQLEGICLQVIGTVLQQH 647

  Fly   647 ITDFYEETFSLVYDLTAKAISPEMWQMLELIYQVFKKDGIDYFIDIMPALHNYVTVDTPAFLSNP 711
            :.:||||.|||.:.||.:.:|.:|||:|.|:::||::||.|||.|:||.|||||||||...:|:.
Frog   648 VLEFYEEIFSLAHSLTCQQVSAQMWQLLPLVFEVFQQDGFDYFTDMMPLLHNYVTVDTDTLMSDT 712

  Fly   712 NRLLAILDMCKTMLTSSPGEDPECHAAKLMEVIILQCKGQ-IDSVIHMFVELALSRLTREVQSSE 775
            ..|..|..|||.:||...|||.|||||||:||:||||||: ||.||.:|||.||.||||||::||
Frog   713 KYLEMIYSMCKKVLTGVAGEDAECHAAKLLEVVILQCKGRGIDQVIPLFVEAALERLTREVKTSE 777

  Fly   776 LRTMCLQVVIAALYYNPQLLLSILDKMSQQNNDS-ISAHFIKQWLHDTDCFLGIHDRKLCVLGLC 839
            ||||||||.||||||:|.|||:.|:.:...||:. ::.|||||||:|.|||||:||||:||||||
Frog   778 LRTMCLQVAIAALYYSPPLLLNTLENLRFPNNEEPVTNHFIKQWLNDVDCFLGLHDRKICVLGLC 842

  Fly   840 TLISLGEAKPQVLSEVAGKIVPALILLFDGLKRAYESRAQEEEEDEEEEDGDDCEEA--LSSDED 902
            .||.| :.:||||::::.:|:||.:|||:||||||...|::|.:.::||||::.|:|  |.||||
Frog   843 ALIEL-DQRPQVLNQMSAQILPAFLLLFNGLKRAYACHAEQENDSDDEEDGEEDEDAAELGSDED 906

  Fly   903 DMDEMAPDYLDKLAEFAKTKGNESGFEVKAEIKDDDADSDGDAEESVGDLNETGLESFTTPIDDE 967
            |:||...:||:.||:.|...|::..:|      ||||:             ||.||.:||.||||
Frog   907 DIDEEGQEYLEILAKQAGEDGDDEDWE------DDDAE-------------ETALEGYTTLIDDE 952

  Fly   968 ENESAIDEYWTFKEVITALSAQDQAWYALLTSNLTPEQAKALQEVVVTADQRKAAKESKLIEKQG 1032
              ::.||||..||.:...|..:|..||..||..|:.:|.|.||::...||||:||.|||:|||.|
Frog   953 --DTPIDEYQIFKAIFQKLQGRDPVWYQALTQGLSEDQGKQLQDIATLADQRRAAHESKMIEKHG 1015

  Fly  1033 GFAFPQTAVPTSFKFGS 1049
            |:.|....||:||.|||
Frog  1016 GYKFNAPVVPSSFNFGS 1032

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
msk	NP_524780.1	SXM1	4..1013	CDD:227943	548/1016 (54%)
msk	NP_524780.1	IBN_N	24..103	CDD:281761	41/78 (53%)
ipo7	XP_012815848.1	SXM1	15..997	CDD:227943	543/1006 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	641	1.000	Domainoid score	I166
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H4659
Inparanoid	1	1.050	1142	1.000	Inparanoid score	I216
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D159062at2759
OrthoFinder	1	1.000	-	-		FOG0002119
OrthoInspector	1	1.000	-	-		otm47650
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1573
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060