DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment MED6 and med6

DIOPT Version :9

Sequence 1:	NP_001163577.1	Gene:	MED6 / 44728	FlyBaseID:	FBgn0024330	Length:	249	Species:	Drosophila melanogaster
Sequence 2:	NP_001002084.1	Gene:	med6 / 415174	ZFINID:	ZDB-GENE-040625-61	Length:	254	Species:	Danio rerio

Alignment Length:	263	Identity:	110/263 - (41%)
Similarity:	157/263 - (59%)	Gaps:	25/263 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MASRQMTNDHLRLSWHDTQMMATLSPQTVMDYFCRKSNPFYDHMCNNETVRMQRLGPEHLHNMIG 65
            ||:..:.::.|.:||.|:..:..|:|..|::||..:||||||..||||.|:|||...:||..::|
Zfish     1 MATVDLRDNLLGISWVDSGWVPILNPSNVLEYFSERSNPFYDRTCNNEVVKMQRSTLDHLTQLVG 65

  Fly    66 LEYILLHVAEPILYVIRKQHRHNPSEATPIADYYIIGGTVYKAPDLANVINSRILNTVVNLQSAF 130
            :||||||..|||||:||||.|.:|::..|:||||||.|.||:||||.:||:||.|:.|..:||||
Zfish    66 VEYILLHTQEPILYIIRKQQRQSPTQVIPLADYYIIAGVVYQAPDLGSVISSRALSAVHGIQSAF 130

  Fly   131 EEASSYARYHPNKGYTWDFSSNKVFSDRSKSDKKDANSAKDENSGTLFQKQRVDMLLAELLRKFP 195
            :||.|:.||||:|||.|.      |.|:.:.::....|.:.|...:|||:||||.||.:|..|||
Zfish   131 DEAMSFCRYHPSKGYWWH------FKDQEEKERVKPKSKRKEEPSSLFQRQRVDTLLLDLRNKFP 189

  Fly   196 P----------PIPPMLQNLQQPPPAGDDLNTARNASEMNN----ATGPLDIKTEGVDMKPPPEK 246
            |          |:|..::...:.|     :.|.:...|...    ...|.....:....||||||
Zfish   190 PTFYQTKPGEKPVPVEVKKEPEVP-----VETVKPQEERETKPPAPPAPPRPPPQTTPNKPPPEK 249

  Fly   247 KSK 249
            :::
Zfish   250 RAR 252

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
MED6	NP_001163577.1	Med6	13..139	CDD:282750	69/125 (55%)
med6	NP_001002084.1	Med6	13..139	CDD:282750	69/125 (55%)
med6	NP_001002084.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..254		13/68 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170588145
Domainoid	1	1.000	161	1.000	Domainoid score	I4002
eggNOG	1	0.900	-	-		E1_COG5097
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3990
Inparanoid	1	1.050	211	1.000	Inparanoid score	I3636
OMA	1	1.010	-	-		QHG55402
OrthoDB	1	1.010	-	-		D1251252at2759
OrthoFinder	1	1.000	-	-		FOG0005042
OrthoInspector	1	1.000	-	-		oto41546
orthoMCL	1	0.900	-	-		OOG6_102673
Panther	1	1.100	-	-	LDO	PTHR13104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2638
SonicParanoid	1	1.000	-	-		X5378
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800