DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment san and RNF113A

DIOPT Version :9

Sequence 1:	NP_524779.1	Gene:	san / 44724	FlyBaseID:	FBgn0024188	Length:	184	Species:	Drosophila melanogaster
Sequence 2:	NP_008909.1	Gene:	RNF113A / 7737	HGNCID:	12974	Length:	343	Species:	Homo sapiens

Alignment Length:	74	Identity:	15/74 - (20%)
Similarity:	26/74 - (35%)	Gaps:	22/74 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 YNDKFYVDVLEAGE----------LAKLAYYNDIVVGA---VC--CRIDNTENQRRLYI---MTL 77
            |.|:.|    |.|.          :.:.::.|.:|...   .|  |.:.:.....|.|:   .|.
Human   244 YEDENY----EVGSDDEEIPFKCFICRQSFQNPVVTKCRHYFCESCALQHFRTTPRCYVCDQQTN 304

  Fly    78 GCLSPYRRL 86
            |..:|.:.|
Human   305 GVFNPAKEL 313

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
san	NP_524779.1	RimI	<27..145	CDD:223532	15/74 (20%)
san	NP_524779.1	Acetyltransf_1	50..130	CDD:278980	10/45 (22%)
RNF113A	NP_008909.1	Important for interaction with SNRNP200/BRR2. /evidence=ECO:0000269\|PubMed:29144457	2..60
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..96
		COG5152	30..322	CDD:227481	15/74 (20%)
		Important for interaction with CXCR4. /evidence=ECO:0000269\|PubMed:28978524	50..61
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..343
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2079
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.030