DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Coprox and HEM13

DIOPT Version :9

Sequence 1:	NP_001285697.1	Gene:	Coprox / 44701	FlyBaseID:	FBgn0021944	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_010329.1	Gene:	HEM13 / 851614	SGDID:	S000002451	Length:	328	Species:	Saccharomyces cerevisiae

Alignment Length:	324	Identity:	176/324 - (54%)
Similarity:	208/324 - (64%)	Gaps:	16/324 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 DKENM--RHRMEILIMEIQAEFCRALEAEENCGQKFKVDRWER-PEGGGGITCVLQDGDVFEKAG 142
            |..|:  |.:||.||...|||..:.||:.:..  ||..|.|.| .:||||.:.|:|||..|||.|
Yeast     6 DPRNLPIRQQMEALIRRKQAEITQGLESIDTV--KFHADTWTRGNDGGGGTSMVIQDGTTFEKGG 68

  Fly   143 VNISVVTGSLPPAAVQQMRARGKNLK----EGASLP------FFASGVSAVIHPRNPHVPTIHFN 197
            ||:|||.|.|.||||..|:|..|||:    ....||      |||.|:|.||||.|||.||.|.|
Yeast    69 VNVSVVYGQLSPAAVSAMKADHKNLRLPEDPKTGLPVTDGVKFFACGLSMVIHPVNPHAPTTHLN 133

  Fly   198 YRYFEVETAKGEKQ-WWFGGGTDLTPYYLCEKDASHFHQTLKSACDEHDPTYYPRFKKWCDDYFR 261
            |||||.....|..| ||||||.||||.||.|:|...|||..|.|.|:||...|||||||||:||.
Yeast   134 YRYFETWNQDGTPQTWWFGGGADLTPSYLYEEDGQLFHQLHKDALDKHDTALYPRFKKWCDEYFY 198

  Fly   262 IKHRNESRGIGGIFFDDIDSPNQEAAFNFVSSCARAVIPSYVPLVRKHKNREYGNNERQWQLLRR 326
            |.||.|:||||||||||.|..:.:.....|..|..|.:|||:.:|::.|:..|...|:|||.:||
Yeast   199 ITHRKETRGIGGIFFDDYDERDPQEILKMVEDCFDAFLPSYLTIVKRRKDMPYTKEEQQWQAIRR 263

  Fly   327 GRYVEFNLIYDRGTKFGLYTPGARYESILMSLPLHARWEYMHEPKSQSEEGKLMKVLKNPKDWV 390
            ||||||||||||||:|||.|||:|.||||||||.||.|.|.|.|...|.|.||::|...|::||
Yeast   264 GRYVEFNLIYDRGTQFGLRTPGSRVESILMSLPEHASWLYNHHPAPGSREAKLLEVTTKPREWV 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coprox	NP_001285697.1	Coprogen_oxidas	88..390	CDD:279549	171/313 (55%)
HEM13	NP_010329.1	Coprogen_oxidas	15..327	CDD:395974	171/313 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157341375
Domainoid	1	1.000	339	1.000	Domainoid score	I155
eggNOG	1	0.900	-	-		E1_COG0408
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76
Inparanoid	1	1.050	342	1.000	Inparanoid score	I407
Isobase	1	0.950	-	0	Normalized mean entropy	S987
OMA	1	1.010	-	-		QHG63158
OrthoFinder	1	1.000	-	-		FOG0003913
OrthoInspector	1	1.000	-	-		oto99847
orthoMCL	1	0.900	-	-		OOG6_101984
Panther	1	1.100	-	-	LDO	PTHR10755
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R557
SonicParanoid	1	1.000	-	-		X2692
TreeFam	1	0.960	-	-
	16	15.740