DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Coprox and cpox

DIOPT Version :9

Sequence 1:	NP_001285697.1	Gene:	Coprox / 44701	FlyBaseID:	FBgn0021944	Length:	390	Species:	Drosophila melanogaster
Sequence 2:	NP_001035183.2	Gene:	cpox / 321294	ZFINID:	ZDB-GENE-030131-9884	Length:	449	Species:	Danio rerio

Alignment Length:	401	Identity:	223/401 - (55%)
Similarity:	283/401 - (70%)	Gaps:	17/401 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RHTISLVSLGTFQLV-----RRTRGPHARGFLLGTG---------LGLASFSAVTYAHSAEAVDP 55
            |...|.:..||.|:.     |.:.|.:.:|..|..|         .|::.|.....|.....|:.
Zfish    51 RGKCSFIKTGTRQMCQSSPRRISLGRYGKGVFLAAGAAAVTGVLAAGVSHFQRAEMATKISRVEE 115

  Fly    56 KVNGVQMNTSRFMAEPITDSKALLGDKENMRHRMEILIMEIQAEFCRALEAEENCGQKFKVDRWE 120
            :...::.....||:.|:||.|.|...|:.|..|||:||||.|:.||||||..:  |..|:||||.
Zfish   116 EDGDIRERCKSFMSPPVTDIKLLEQRKDEMSTRMEMLIMETQSAFCRALEQVD--GGSFRVDRWS 178

  Fly   121 RPEGGGGITCVLQDGDVFEKAGVNISVVTGSLPPAAVQQMRARGKNLK-EGASLPFFASGVSAVI 184
            |.||||||:||:|||.:|||||||:|||.|:|...|.:|||:|||.|| :...|||.|.|||:||
Zfish   179 RKEGGGGISCVMQDGKIFEKAGVNVSVVYGNLTEEAARQMRSRGKILKGKDGKLPFRAMGVSSVI 243

  Fly   185 HPRNPHVPTIHFNYRYFEVETAKGEKQWWFGGGTDLTPYYLCEKDASHFHQTLKSACDEHDPTYY 249
            ||:|||:||:||||||||:|.|.|.|||||||||||||.|:..:||:|||:|||.|||:|.|.||
Zfish   244 HPKNPHIPTVHFNYRYFEIEEADGTKQWWFGGGTDLTPVYIDLEDATHFHKTLKEACDKHHPKYY 308

  Fly   250 PRFKKWCDDYFRIKHRNESRGIGGIFFDDIDSPNQEAAFNFVSSCARAVIPSYVPLVRKHKNREY 314
            |.||||||:||.|:||.|:||||||||||:|||:|:..||||.|||:.|:|.|:|:|.||.|..:
Zfish   309 PDFKKWCDNYFYIRHRGETRGIGGIFFDDLDSPDQDEVFNFVRSCAKTVVPCYLPIVYKHLNDSF 373

  Fly   315 GNNERQWQLLRRGRYVEFNLIYDRGTKFGLYTPGARYESILMSLPLHARWEYMHEPKSQSEEGKL 379
            ...|:.||.:||||||||||:||||.||||.|||:|.|||||||||.|||||||||...::|.::
Zfish   374 TPEEKDWQQVRRGRYVEFNLVYDRGVKFGLATPGSRIESILMSLPLTARWEYMHEPTKGTKEAEM 438

  Fly   380 MKVLKNPKDWV 390
            :::|:|||.|:
Zfish   439 LEILRNPKQWI 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Coprox	NP_001285697.1	Coprogen_oxidas	88..390	CDD:279549	199/302 (66%)
cpox	NP_001035183.2	Coprogen_oxidas	148..449	CDD:279549	199/302 (66%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573896
Domainoid	1	1.000	443	1.000	Domainoid score	I514
eggNOG	1	0.900	-	-		E1_COG0408
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H76
Inparanoid	1	1.050	465	1.000	Inparanoid score	I1520
OMA	1	1.010	-	-		QHG63158
OrthoDB	1	1.010	-	-		D1080991at2759
OrthoFinder	1	1.000	-	-		FOG0003913
OrthoInspector	1	1.000	-	-		oto39906
orthoMCL	1	0.900	-	-		OOG6_101984
Panther	1	1.100	-	-	LDO	PTHR10755
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R557
SonicParanoid	1	1.000	-	-		X2692
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800