DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ergic53 and LMAN1L

DIOPT Version :9

Sequence 1:	NP_524776.1	Gene:	ergic53 / 44679	FlyBaseID:	FBgn0035909	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_068591.2	Gene:	LMAN1L / 79748	HGNCID:	6632	Length:	526	Species:	Homo sapiens

Alignment Length:	534	Identity:	170/534 - (31%)
Similarity:	247/534 - (46%)	Gaps:	84/534 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PTFLAILCFLAWNPSSEATGNLSPGAVGVHRRFEYKYSFKPPYLAQKDGTVPFWEYGGNAIASSE 67
            |.|..:|..|  :|.|..||  .|..    ||||||.|||.|.||.....:|||.:.|:||...|
Human     9 PLFCLLLLLL--DPHSPETG--CPPL----RRFEYKLSFKGPRLALPGAGIPFWSHHGDAILGLE 65

  Fly    68 SVRVAPSLRSQKGAIWTKSQTNFDWWDVEIVFRVTGRGRIGADGLAFWYTTEKGDYNGPVFGSSD 132
            .||:.||:|::.||:|:::...|..|:||:..||||.||.||.|:|.|||..:| :.|.|.|...
Human    66 EVRLTPSMRNRSGAVWSRASVPFSAWEVEVQMRVTGLGRRGAQGMAVWYTRGRG-HVGSVLGGLA 129

  Fly   133 RWNGLAIMFDSFDNDNKHNNPYISAVLNDGTKLYDHAEDGTTQLLSGCLRDFRNKPFPTRARIEY 197
            .|:|:.|.|||...|.: ::|.|..:.:||....:...||.:|.|..|..||||:|.|.||||.|
Human   130 SWDGIGIFFDSPAEDTQ-DSPAIRVLASDGHIPSEQPGDGASQGLGSCHWDFRNRPHPFRARITY 193

  Fly   198 YNNVLTVMIHNGMSNNNDDYELCLRADGVNLPKNGYFGISAATGGLADDHDVFHFLTTSL-HAAG 261
            :...|.:.:::|:: .:|..|.|:....:.|...|:||:|||||.|||||||..|||.|| ..:.
Human   194 WGQRLRMSLNSGLT-PSDPGEFCVDVGPLLLVPGGFFGVSAATGTLADDHDVLSFLTFSLSEPSP 257

  Fly   262 QVQEQPKVENQE-KLTQEYKEYQDKLEKQKQEYKKDHPDEHKDEEDWEEFYESENQRELRQIWQG 325
            :|..||.:|.|: :|.::.:....:|....:|......|.....|....|...|.....|:|.|.
Human   258 EVPPQPFLEMQQLRLARQLEGLWARLGLGTREDVTPKSDSEAQGEGERLFDLEETLGRHRRILQA 322

  Fly   326 QSQIADHLRELSRKVDEIIGRQETTLSLVSRNAGQALP--------------PPAAGG-----VP 371
            ...::..|.:..|:..:.:|           ..|||.|              .|..||     :.
Human   323 LRGLSKQLAQAERQWKKQLG-----------PPGQARPDGGWALDASCQIPSTPGRGGHLSMSLN 376

  Fly   372 QQQLPVGAVSRSDVDLLLTNQNMLLSSIREIRQLVGDINVRTDNIQTNQKHAPTAQIQSTGYDVQ 436
            :....|||        ||..|..||.:::|:|    |..||.         |..||:......::
Human   377 KDSAKVGA--------LLHGQWTLLQALQEMR----DAAVRM---------AAEAQVSYLPVGIE 420

  Fly   437 TLIAEMRD--GMNQVKQGITHVGQRLAAPQGAAQVANCPTG------NCVGVTLFLSVTVVQLLL 493
            ....|:..  |:.|         :.|..|..||..|..|.|      :|:...:||...::|.:.
Human   421 HHFLELDHILGLLQ---------EELRGPAKAAAKAPRPPGQPPRASSCLQPGIFLFYLLIQTVG 476

  Fly   494 VFIYNVFK---NRS 504
            .|.|..|:   |:|
Human   477 FFGYVHFRQELNKS 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ergic53	NP_524776.1	lectin_ERGIC-53_ERGL	33..258	CDD:173890	101/225 (45%)
LMAN1L	NP_068591.2	lectin_L-type	31..253	CDD:301310	100/224 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157598
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3838
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1377709at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	6	5.810