DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ergic53 and lman1

DIOPT Version :9

Sequence 1:	NP_524776.1	Gene:	ergic53 / 44679	FlyBaseID:	FBgn0035909	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_001373163.1	Gene:	lman1 / 559775	ZFINID:	ZDB-GENE-060201-4	Length:	503	Species:	Danio rerio

Alignment Length:	510	Identity:	213/510 - (41%)
Similarity:	313/510 - (61%)	Gaps:	47/510 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SSEATGNLSPGAVGVHRRFEYKYSFKPPYLAQKDGTVPFWEYGGNAIASSESVRVAPSLRSQKGA 81
            :..|||:|.      |||||||||||.|:|.|.||.:|||.:.||||.||:.||:.||||||||:
Zfish    27 ADSATGDLP------HRRFEYKYSFKGPHLTQSDGRIPFWIHTGNAIPSSDQVRITPSLRSQKGS 85

  Fly    82 IWTKSQTNFDWWDVEIVFRVTGRGRIGADGLAFWYTTEKGDYNGPVFGSSDRWNGLAIMFDSFDN 146
            :||||..:|:.|:.|:.|||:||||:||||||.|:|..:| ..|||:|::|:|||:.|.||||||
Zfish    86 VWTKSPVSFEHWEAEVAFRVSGRGRMGADGLAIWFTAGQG-LEGPVYGAADQWNGVGIFFDSFDN 149

  Fly   147 DNKHNNPYISAVLNDGTKLYDHAEDGTTQLLSGCLRDFRNKPFPTRARIEYYNNVLTVMIHNGMS 211
            |.|.|||.:..|.|:|..::||..|||||.|..|||||||||:|.|.:|.||...|:|.|:||.:
Zfish   150 DGKKNNPAVLVVGNNGKLVFDHQNDGTTQALGTCLRDFRNKPYPIRTKITYYKQTLSVFINNGFT 214

  Fly   212 NNNDDYELCLRADGVNLPKNGYFGISAATGGLADDHDVFHFLTTSLHAAGQ-----VQEQPKVEN 271
            .:.||||.|.:.:.:.:|..||||||||||||||||||..||...|...||     .:|.|| |.
Zfish   215 PDKDDYEFCTKVENMIIPGTGYFGISAATGGLADDHDVLSFLLFRLTEPGQNLPPPEKEIPK-EE 278

  Fly   272 QEKLTQEYKEYQDKLEKQKQEYKKDHPDEHKDEEDWEEFYESENQRELRQIWQGQSQIADHLREL 336
            ::|..:|::.:|..|:|:|:|::|:|||  ...:..|:.|||.|.||:||:::||::|...:::|
Zfish   279 KDKYQEEFENFQQALDKRKEEFQKEHPD--VQGQPIEDLYESVNDREIRQVFEGQNRIHLEIKQL 341

  Fly   337 SRKVDEIIGRQETTLSLVSRNAGQALPPPAAGGVPQQQLPVGAVSRSDVDLLLTNQNMLLSSIRE 401
            :|::..|:..|...:|:::....:......:|..|..:|          :.::|.|:.:|.:|.|
Zfish   342 NRQLAMILDEQRRYVSVITDEINKRTSQAQSGQAPSHEL----------ETIITTQHEVLKNINE 396

  Fly   402 IRQLVGDINVRTDNIQTNQKHAPTAQIQST-----GYDVQTLIAEMRDGMNQVKQGITHVGQRLA 461
            :|          :::..:.|.....|.|..     .|:......::::.::.||:.|.|:.|:.|
Zfish   397 VR----------NSLSGSLKQLAMGQHQGNAGGLGSYETVQHFNDIKEHLHVVKRNIEHIIQKNA 451

  Fly   462 APQGAAQVANC----PTGNCVGVTLFLSVTVVQLLLVFIYNVFKNRSEAQAKKFY 512
            .|   |:...|    |...|:..|.||...|:|.||.|.|.::|::.||.||||:
Zfish   452 NP---AEKLKCPELPPLPTCLSTTHFLIFIVIQSLLFFGYIMYKSQQEAAAKKFF 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ergic53	NP_524776.1	lectin_ERGIC-53_ERGL	33..258	CDD:173890	133/224 (59%)
lman1	NP_001373163.1	lectin_ERGIC-53_ERGL	37..261	CDD:173890	133/224 (59%)
lman1	NP_001373163.1	SbcC	276..>410	CDD:223496	40/156 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	296	1.000	Domainoid score	I1454
eggNOG	1	0.900	-	-		E1_KOG3838
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4070
Inparanoid	1	1.050	392	1.000	Inparanoid score	I1939
OMA	1	1.010	-	-		QHG48094
OrthoDB	1	1.010	-	-		D1377709at2759
OrthoFinder	1	1.000	-	-		FOG0006530
OrthoInspector	1	1.000	-	-		oto39473
orthoMCL	1	0.900	-	-		OOG6_105872
Panther	1	1.100	-	-	LDO	PTHR12223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4179
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840