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Protein Alignment ergic53 and LMAN1

DIOPT Version :9

Sequence 1:	NP_524776.1	Gene:	ergic53 / 44679	FlyBaseID:	FBgn0035909	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_005561.1	Gene:	LMAN1 / 3998	HGNCID:	6631	Length:	510	Species:	Homo sapiens

Alignment Length:	520	Identity:	214/520 - (41%)
Similarity:	319/520 - (61%)	Gaps:	30/520 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MRPTFLAILCFLAWNPSSEATGNLSPGAVGVHRRFEYKYSFKPPYLAQKDGTVPFWEYGGNAIAS 65
            :||.|.|:|..|......:..|. .|.....|||||||||||.|:|.|.|||||||.:.||||.|
Human    13 VRPLFCALLLSLGRFVRGDGVGG-DPAVALPHRRFEYKYSFKGPHLVQSDGTVPFWAHAGNAIPS 76

  Fly    66 SESVRVAPSLRSQKGAIWTKSQTNFDWWDVEIVFRVTGRGRIGADGLAFWYTTEKGDYNGPVFGS 130
            |:.:||||||:||:|::|||::..|:.|:||:.|||||||||||||||.||...:| ..||||||
Human    77 SDQIRVAPSLKSQRGSVWTKTKAAFENWEVEVTFRVTGRGRIGADGLAIWYAENQG-LEGPVFGS 140

  Fly   131 SDRWNGLAIMFDSFDNDNKHNNPYISAVLNDGTKLYDHAEDGTTQLLSGCLRDFRNKPFPTRARI 195
            :|.|||:.|.|||||||.|.|||.|..:.|:|...|||..||.:|.|:.|.|||||||:|.||:|
Human   141 ADLWNGVGIFFDSFDNDGKKNNPAIVIIGNNGQIHYDHQNDGASQALASCQRDFRNKPYPVRAKI 205

  Fly   196 EYYNNVLTVMIHNGMSNNNDDYELCLRADGVNLPKNGYFGISAATGGLADDHDVFHFLTTSLHAA 260
            .||.|.|||||:||.:.:.:|||.|.:.:.:.:|..|:||||||||||||||||..|||..|...
Human   206 TYYQNTLTVMINNGFTPDKNDYEFCAKVENMIIPAQGHFGISAATGGLADDHDVLSFLTFQLTEP 270

  Fly   261 GQVQEQPKVE----NQEKLTQEYKEYQDKLEKQKQEYKKDHPDEHKDEEDWEEFYESENQRELRQ 321
            |:....|..|    .:||..:|::.:|.:|:|:|:|::|.|||  ...:..||.:||...|||||
Human   271 GKEPPTPDKEISEKEKEKYQEEFEHFQQELDKKKEEFQKGHPD--LQGQPAEEIFESVGDRELRQ 333

  Fly   322 IWQGQSQIADHLRELSRKVDEIIGRQETTLSLVSRNAGQALPPPAAGGVPQQQLPVGAVSRSDVD 386
            :::||::|...:::|:|::|.|:..|...:|.::....:     ...|:|.|.   |.:::.::|
Human   334 VFEGQNRIHLEIKQLNRQLDMILDEQRRYVSSLTEEISK-----RGAGMPGQH---GQITQQELD 390

  Fly   387 LLLTNQNMLLSSIREIRQLVGDINVRTDNIQTNQKHAPTAQIQSTGYDVQTLIAEMRDGMNQVKQ 451
            .::..|:.:|..:.|::..:.:    |..:.:..:|..:|   ...|:......::::.::.||:
Human   391 TVVKTQHEILRQVNEMKNSMSE----TVRLVSGMQHPGSA---GGVYETTQHFIDIKEHLHIVKR 448

  Fly   452 GITHVGQRLAAPQGAAQVANCPT----GNCVGVTLFLSVTVVQLLLVFIYNVFKNRSEAQAKKFY 512
            .|.::.||   ...:.:...||.    .:|:....|:...|||.:|...|.:::::.||.||||:
Human   449 DIDNLVQR---NMPSNEKPKCPELPPFPSCLSTVHFIIFVVVQTVLFIGYIMYRSQQEAAAKKFF 510

Fly 513 512
Human 511 510

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.