DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ergic53 and ile-1

DIOPT Version :9

Sequence 1:	NP_524776.1	Gene:	ergic53 / 44679	FlyBaseID:	FBgn0035909	Length:	512	Species:	Drosophila melanogaster
Sequence 2:	NP_492548.1	Gene:	ile-1 / 172799	WormBaseID:	WBGene00002070	Length:	492	Species:	Caenorhabditis elegans

Alignment Length:	503	Identity:	199/503 - (39%)
Similarity:	299/503 - (59%)	Gaps:	55/503 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 VHRRFEYKYSFKPPYLAQKDGTVPFWEYGGNAIASSESVRVAPSLRSQKGAIWTK----SQTNFD 91
            |.::||||:||:.|.|||:||::|||...|:||||.|.:|:|||:||:||..|.|    ...||
Worm    24 VFKKFEYKHSFRAPNLAQRDGSIPFWIVSGDAIASGEQLRLAPSMRSRKGIAWNKRAFLESENF- 87

  Fly    92 WWDVEIVFRVTGRGRIGADGLAFWYTTEKGDYNGPVFGSSDRWNGLAIMFDSFDNDNKHNNPYIS 156
              .|:|..::.|:||:|||||..|||::.|.. |||||.:|.|.|:.:..||||||.:.|||.:|
Worm    88 --QVDIALKIGGQGRVGADGLGIWYTSQLGAL-GPVFGGNDFWTGMGLFLDSFDNDGQKNNPQVS 149

  Fly   157 AVLNDGTKLYDHAEDGTTQLLSGCLRDFRNKPFPTRARIEYYNNVLTVMIHNGMSNNNDDYELCL 221
            .:|||||:.|||..||:.|:||.|.|||||||:|.|.||||..|||||.|.:|| .....||||:
Worm   150 LMLNDGTRSYDHHTDGSQQILSSCQRDFRNKPYPVRIRIEYLKNVLTVHIDDGM-QPTPRYELCM 213

  Fly   222 RADGVNLPKNGYFGISAATGGLADDHDVFHFLTTSLH--------AAGQVQEQPKVENQEKLTQE 278
            ||:.:.||:|||||:|||||||||||||..|...||.        .|.|:.:|.|.:..|:..::
Worm   214 RAENIFLPRNGYFGVSAATGGLADDHDVLDFSVFSLFNEQQKPVPVAEQIPQQEKQKYDEEFERQ 278

  Fly   279 YKEYQDKLEKQKQEYKKDHPDEHKDEEDWE--EFYESENQRELRQIWQGQSQIADHLRELSRKVD 341
            .|||    |:::.::|:.|||:.|::::::  ::||....||||.|::.|:.|...::.:.:::.
Worm   279 MKEY----EQERAKFKEQHPDKVKEDDEYDPNKYYEDATARELRLIYESQNAIHQVMQNMDQRLA 339

  Fly   342 EIIGRQETTLSLVSRNAGQALPPPAAGGVPQQQLPVGAVSRSDVDLLLTNQNMLLSSIREIRQLV 406
            :|...|.:.::....::|.|.|.|.|.|        |:..:.:.:.::|:...|..:||:::|.|
Worm   340 QIQQAQTSGVAAAVPHSGGAAPAPVAAG--------GSFQQHEKNEVITSLRDLTQTIRDMKQYV 396

  Fly   407 GDINVRTDNIQTN--QKHAPTAQIQSTGYD-VQTLIAEMRDGMNQVKQGITHVGQRLAAPQGAAQ 468
            .:|..:|.||...  |..|....:.|:.:. |.:|:.|:|         .....|...:..|||
Worm   397 NEIFTKTYNIDQKIAQGGAGAGGVDSSMHQKVDSLLNELR---------TVRATQIQTSGPGAA- 451

  Fly   469 VANCPTGNCVGVTLFLSVTVVQ----LLLVFIYNVFKNRSEAQAKKFY 512
             ||||..:||..|:|:.:..:|    :.:||:      ||:....|||
Worm   452 -ANCPNISCVSSTIFMLIIFIQSAIIVAVVFV------RSKQDKAKFY 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ergic53	NP_524776.1	lectin_ERGIC-53_ERGL	33..258	CDD:173890	128/228 (56%)
ile-1	NP_492548.1	lectin_ERGIC-53_ERGL	26..250	CDD:173890	128/228 (56%)
ile-1	NP_492548.1	UPF0242	<250..346	CDD:369080	24/99 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166964
Domainoid	1	1.000	268	1.000	Domainoid score	I986
eggNOG	1	0.900	-	-		E1_KOG3838
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H4070
Inparanoid	1	1.050	351	1.000	Inparanoid score	I1339
Isobase	1	0.950	-	0	Normalized mean entropy	S3759
OMA	1	1.010	-	-		QHG48094
OrthoDB	1	1.010	-	-		D1377709at2759
OrthoFinder	1	1.000	-	-		FOG0006530
OrthoInspector	1	1.000	-	-		oto18863
orthoMCL	1	0.900	-	-		OOG6_105872
Panther	1	1.100	-	-	LDO	PTHR12223
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5289
SonicParanoid	1	1.000	-	-		X4179
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790