DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and DCLK1

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001317000.1	Gene:	DCLK1 / 9201	HGNCID:	2700	Length:	740	Species:	Homo sapiens

Alignment Length:	500	Identity:	146/500 - (29%)
Similarity:	219/500 - (43%)	Gaps:	90/500 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 SGTAASAAAAKASNNNNNNHPRGSGD-----SGIRSGSGISCSNTDNSCSQSQSDGQNELTRYSS 65
            :||..|..:...|..:.:..|...|.     |....||..|.::|....|..::||       ..
Human   315 NGTPGSQLSTPRSGKSPSPSPTSPGSLRKQRSSQHGGSSTSLASTKVCSSMDENDG-------PG 372

  Fly    66 EDVSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYA 130
            |:|| .|..:.|                                 :|..|.||: |..:|:|.:|
Human   373 EEVS-EEGFQIP---------------------------------ATITERYKV-GRTIGDGNFA 402

  Fly   131 SVQTCVNIYTDLEYAVKVIDKIPGHARARVFR-EVETFHHCQGHLGILQLIEFFEDDEKFYLVFE 194
            .|:.||...|..|||:|:|.|.....:..:.: ||......: |..|:.|||..:...:.|||.|
Human   403 VVKECVERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVK-HPNIVLLIEEMDVPTELYLVME 466

  Fly   195 KINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILCVK-TDSLCPIKI 258
            .:.||.|...|.....::|.:||.::..:||.:.:||...|.|||:||||:|..: .|....:|:
Human   467 LVKGGDLFDAITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSKSLKL 531

  Fly   259 CDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYIL 323
            .||.|      .|.:..|     |.|..|:..::|||:    :.|.. |..:.|:|:.|||.|||
Human   532 GDFGL------ATIVDGP-----LYTVCGTPTYVAPEI----IAETG-YGLKVDIWAAGVITYIL 580

  Fly   324 LCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKA 388
            |||:|||.|: |:|            ||:||:.|..|...||...|.:|||.||:||:.:|:...
Human   581 LCGFPPFRGS-GDD------------QEVLFDQILMGQVDFPSPYWDNVSDSAKELITMMLLVDV 632

  Fly   389 SNRLSAEAVLNHPWIR---MCEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKR 450
            ..|.||..||.|||:.   :.|.|...|..|:..|...|..   :.:.:|..:|..|.:|:..:|
Human   633 DQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGP---KPNSTAAGVSVIATTALDKER 694

  Fly   451 VVL-----QHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPP 490
            .|.     |....||......|.:...|:.|..:.|:...:|..|
Human   695 QVFRRRRNQDVRSRYKAQPAPPELNSESEDYSPSSSETVRSPNSP 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	104/289 (36%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	103/287 (36%)
DCLK1	NP_001317000.1	DCX1_DCLK1	55..143	CDD:340660
		DCX2	182..265	CDD:340589
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	287..378		17/70 (24%)
		STKc_DCKL1	383..650	CDD:271085	107/330 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	697..740		8/42 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920