DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and MKNK1

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_003675.3	Gene:	MKNK1 / 8569	HGNCID:	7110	Length:	453	Species:	Homo sapiens

Alignment Length:	463	Identity:	212/463 - (45%)
Similarity:	281/463 - (60%)	Gaps:	71/463 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 EEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHAR 157
            :..:||:|:.|.:.|| ...|:::||||.|:|||||||.||..|::....|||||:|:|..||:|
Human    13 DRRRKKKRRGRATDSL-PGKFEDMYKLTSELLGEGAYAKVQGAVSLQNGKEYAVKIIEKQAGHSR 76

  Fly   158 ARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKE 222
            :||||||||.:.|||:..||:||||||||.:|||||||:.||.:|:.||:...|:|.|||:::::
Human    77 SRVFREVETLYQCQGNKNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKQKHFNEREASRVVRD 141

  Fly   223 IASGLDFLHKK-----------------------------------------GIAHRDLKPENIL 246
            :|:.|||||.|                                         |||||||||||||
Human   142 VAAALDFLHTKDKVSLCHLGWSAMAPSGLTAAPTSLGSSDPPTSASQVAGTTGIAHRDLKPENIL 206

  Fly   247 CVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRC 311
            |...:.:.|:||||||||||:|.... .:|..||:|.||.||||:||||||::|..:|.:|||||
Human   207 CESPEKVSPVKICDFDLGSGMKLNNS-CTPITTPELTTPCGSAEYMAPEVVEVFTDQATFYDKRC 270

  Fly   312 DLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEA 376
            |||||||:.||:|.|||||.|:||.||||:|||.||.||..||||||||.:.||:.:|..:|.||
Human   271 DLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRVCQNKLFESIQEGKYEFPDKDWAHISSEA 335

  Fly   377 KDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQF 441
            |||||.|||:.|..||||..||.|||::  .|.|        .|.|.||..::|| .|..:::.|
Human   336 KDLISKLLVRDAKQRLSAAQVLQHPWVQ--GQAP--------EKGLPTPQVLQRN-SSTMDLTLF 389

  Fly   442 AESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRS-------- 498
            |..|:|:.|.:.||         |...:.:..:|..|.......:|.......|.|:
Human   390 AAEAIALNRQLSQH---------EENELAEEPEALADGLCSMKLSPPCKSRLARRRALAQAGRGE 445

  Fly   499 QRNPASSL 506
            .|:|.::|
Human   446 DRSPPTAL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	179/328 (55%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	179/326 (55%)
MKNK1	NP_003675.3	STKc_Mnk1	34..363	CDD:271076	180/329 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37838
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2073
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002552
OrthoInspector	1	1.000	-	-		otm40762
orthoMCL	1	0.900	-	-		OOG6_106134
Panther	1	1.100	-	-	LDO	PTHR24349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5431
SonicParanoid	1	1.000	-	-		X1678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.750