DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and DCLK3

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001381601.1	Gene:	DCLK3 / 85443	HGNCID:	19005	Length:	817	Species:	Homo sapiens

Alignment Length:	390	Identity:	117/390 - (30%)
Similarity:	180/390 - (46%)	Gaps:	56/390 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GQNELTRYSSEDVSGNESSEAPNMTEVERQ-------AELNRHKEEMQKKRRKKRISS------S 107
            |..:|.|...|:... |..:.|.|:...|.       |:|.:..:...::.:.:|.|.      .
Human   452 GFEKLRRTRGEEKEA-EKEKKPCMSGGRRMTLRDDQPAKLEKEPKTRPEENKPERPSGRKPRPMG 515

  Fly   108 LHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQG 172
            :.::..::.|: ||.::|:|.:|.|:.|.:..|...||:|:|||.....:..:............
Human   516 IIAANVEKHYE-TGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKEDMVDSEILIIQSLS 579

  Fly   173 HLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAH 237
            |..|::|.|.:|.|.:.||:.|.:.||.|...|.|.:.|.|.:|:.:|.::...|..:|.|.|.|
Human   580 HPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSIVH 644

  Fly   238 RDLKPENILCVKT-DSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFV 301
            |||||||:|..:. |....:|:.||.|...:           ...:.|..|:..::|||::
Human   645 RDLKPENLLVQRNEDKSTTLKLADFGLAKHV-----------VRPIFTVCGTPTYVAPEIL---- 694

  Fly   302 GEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPE 366
             ....|....|:|:.|||.||||||:|||             .:....|:.||..||.|||.|..
Human   695 -SEKGYGLEVDMWAAGVILYILLCGFPPF-------------RSPERDQDELFNIIQLGHFEFLP 745

  Fly   367 AEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWI----------RMCEQEPPASKHGR-RHK 420
            ..|.::||.||||:|.|||.....|.:|..||.||||          |..:..|.:..|.| :||
Human   746 PYWDNISDAAKDLVSRLLVVDPKKRYTAHQVLQHPWIETAGKTNTVKRQKQVSPSSEGHFRSQHK 810

Fly 421 420
Human 811 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	97/288 (34%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	97/286 (34%)
DCLK3	NP_001381601.1	DCX_DCLK3	93..177	CDD:340528
DCLK3	NP_001381601.1	STKc_DCKL3	524..781	CDD:271087	96/286 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920