Protein Alignment Lk6 and HSL1

DIOPT Version :9

• Sequence 1: NP_651986.2
• Gene: Lk6 / 44672
• FlyBaseID: FBgn0017581
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: NP_012821.2
• Gene: HSL1 / 853760
• SGDID: S000001584
• Length: 1518
• Species: Saccharomyces cerevisiae
• Alignment Length: 1284
• Identity: 239/1284 - (18%)
• Similarity: 429/1284 - (33%)
• Gaps: 468/1284 - (36%)

  Fly     4 PKS--GTAASAAAAKASNNNNNNHPRGSGDSGIRSGSGISCSNTDNSCSQSQSDGQNELTRYSSE 66
            ||.  .:.|..||.:|....|:|..|.||..              ....||.:|....|::..|.
Yeast    12 PKGRPSSLAKKAAKRAMAKVNSNPKRASGHL--------------ERVVQSVNDATKRLSQPDST 62

  Fly    67 DVSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYAS 131
            .....:||                        :||.|.:..        .:|| |:.||:|:...
Yeast    63 VSVATKSS------------------------KRKSRDTVG--------PWKL-GKTLGKGSSGR 94

  Fly   132 VQTCVNIYTDLEYAVKVIDK------------IP-GHARARVFREV--------ETFHHCQ---- 171
            |:...|:.|....|:|::.|            :| .::.:.|...|        |..:|.|
Yeast    95 VRLAKNMETGQLAAIKIVPKKKAFVHCSNNGTVPNSYSSSMVTSNVSSPSIASREHSNHSQTNPY 159

  Fly   172 ------------GHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIA 224
                        .|..::.|.|.:|:..:.|||.|.::||.|...:.......|.||....|:|.
Yeast   160 GIEREIVIMKLISHTNVMALFEVWENKSELYLVLEYVDGGELFDYLVSKGKLPEREAIHYFKQIV 224

  Fly   225 SGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSA 289
            .|:.:.|...|.||||||||:|..|.:.  .|||.||.:.:       :..|  ...|.|..||.
Yeast   225 EGVSYCHSFNICHRDLKPENLLLDKKNR--RIKIADFGMAA-------LELP--NKLLKTSCGSP 278

  Fly   290 EFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLF 354
            .:.:||:|   :|.. |:....|:||.|::.:.||.|:.||              |....::||.
Yeast   279 HYASPEIV---MGRP-YHGGPSDVWSCGIVLFALLTGHLPF--------------NDDNIKKLLL 325

  Fly   355 ESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASK----- 414
            : :|.|.:..|.    ::|.||:||||.:||.....|::.:.:|.||.|:..: :.|.:|
Yeast   326 K-VQSGKYQMPS----NLSSEARDLISKILVIDPEKRITTQEILKHPLIKKYD-DLPVNKVLRKM 384

  Fly   415 ------HGRRHKALQTPSNIRRN----------------------HQSAREI--SQFAESAMAVK 449
                  .|:.:..|...:|:..:                      |..:||:  ::..:..|:.:
Yeast   385 RKDNMARGKSNSDLHLLNNVSPSIVTLHSKGEIDESILRSLQILWHGVSRELITAKLLQKPMSEE 449

  Fly   450 RVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPPGHY---TRN----RSQRNPASSLC 507
            ::   .:|:...| |:|.:|...|.:.....:.|:...:|...|   |.|    ||:.|...:|
Yeast   450 KL---FYSLLLQY-KQRHSISLSSSSENKKSATESSVNEPRIEYASKTANNTGLRSENNDVKTL- 509

  Fly   508 GYGGRMSSMHGQRANSRRSSRNASRNA---------SAIYPNSGGFKTLNVHEEDDDDEGLEA-- 561
                     |....:|..:|.....||         :.:......|....:.:.:.|....||
Yeast   510 ---------HSLEIHSEDTSTVNQNNAITGVNTEINAPVLAQKSQFSINTLSQPESDKAEAEAVT 565

  Fly   562 -------------------FGHIDDDDEWSRSRREYQQQCETLGEDRFRRQSGSEGDEVEDDE-- 605
                               :..|.     |||||..:     |...|....:.:..:.|.|:|
Yeast   566 LPPAIPIFNASSSRIFRNSYTSIS-----SRSRRSLR-----LSNSRLSLSASTSRETVHDNEMP 620

  Fly   606 ----------------------------------------------------------------- 605
                                                                             
Yeast   621 LPQLPKSPSRYSLSRRAIHASPSTKSIHKSLSRKNIAATVAARRTLQNSASKRSLYSLQSISKRS 685

  Fly   606 --------------------DGENEDYQHYKHYWRELDEEEGDDYLYEQ--QQRVDDKFGEEEFE 648
                                :..|:...|      .|:.:...:.|.:|  .....|:..|||.:
Yeast   686 LNLNDLLVFDDPLPSKKPASENVNKSEPH------SLESDSDFEILCDQILFGNALDRILEEEED 744

  Fly   649 DEPKEETQ----------ADNLKLSKAYVEQVGE-----TNVEKS------KPQDDNGG------ 686
            :|.:.:||          ||...:|.....:..|     |.:||:      ||.::..|
Yeast   745 NEKERDTQRQRQNDTKSSADTFTISGVSTNKENEGPEYPTKIEKNQFNMSYKPSENMSGLSSFPI 809

  Fly   687 YIREDLIMDNMDMKKNTQQSEFAKLT-----IMRNDAQTEENKIMQQQDEEKKE--------EKQ 738
            :.:|:.:..:...::..:::..:.:|     :.:.:....|.||.::|.::|.:        :.|
Yeast   810 FEKENTLSSSYLEEQKPKRAALSDITNSFNKMNKQEGMRIEKKIQREQLQKKNDRPSPLKPIQHQ 874

  Fly   739 QDDVDG-AKKQG-------PSSDISATTITDNNKLQT----------PVMTTTHINNWQTGDAIE 785
            :..|:. ...||       |..:||...   |:|:::          |....||    :.|....
Yeast   875 ELRVNSLPNDQGKPSLSLDPRRNISQPV---NSKVESLLQGLKFKKEPASHWTH----ERGSLFM 932

  Fly   786 DDDVKLLDSISDLNEKLPEIYETANIVVNSAAVPAASTPAASATRPPTDNPEEDDSNVTKPTTTA 850
            .:.|:        :|| |  .:.:::.:.|:.||.  |..|:::|.|:...|  .|.:.||..:.
Yeast   933 SEHVE--------DEK-P--VKASDVSIESSYVPL--TTVATSSRDPSVLAE--SSTIQKPMLSL 982

  Fly   851 EGTTMQT--TF----------------GMSAEEEKPVALSHTAGHHS-------KTGRTVNF--- 887
            ..:.:.|  ||                .:...:.:.||:||.....|       ::....|.
Yeast   983 PSSFLNTSMTFKNLSQILADDGDDKHLSVPQNQSRSVAMSHPLRKQSAKISLTPRSNLNANLSVK 1047

  Fly   888 ----APDAYQNDEDADIDEDDDYDDEENLHEHSKQQLPSNAYTRKQRQQHQRYIVPRYQLADQVP 948
                :|.:|.::   |:|...|..        ...::|:|.:|.:..|.
Yeast  1048 RNQGSPGSYLSN---DLDGISDMT--------FAMEIPTNTFTAQAIQL---------------- 1085

  Fly   949 QRQHTENWRYRT-----------------HHSQEQQPTADYRKYRPPFS 980
            ....|:|.:..|                 :.|:|::|......|.|.::
Yeast  1086 MNNDTDNNKINTSPKASSFTKEKVIKSAAYISKEKEPDNSDTNYIPDYT 1134

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	90/324 (28%)
		S_TKc	117..403	CDD:214567	90/322 (28%)
HSL1	NP_012821.2	STKc_BRSK1_2	79..369	CDD:270983	90/332 (27%)
		AMPKA_C_like	1347..1517	CDD:418410

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000