DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lk6 and CPK19

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_176386.2	Gene:	CPK19 / 842490	AraportID:	AT1G61950	Length:	551	Species:	Arabidopsis thaliana

Alignment Length:	596	Identity:	159/596 - (26%)
Similarity:	251/596 - (42%)	Gaps:	128/596 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 DVSGNESSEAPN--MTEVER------------QAELNRHKEEM---QKKRRKKRISSSLHSSTFQ 114
            |:||.:::|..:  :|..|:            |..:..||..:   |.:.::|.|:....|:..|
plant    18 DISGEQNTEVKSREITPKEQPRQRQPAPRAKFQIVVQPHKLPLPLPQPQEKQKLINHQKQSTLQQ 82

  Fly   115 -------------ELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDK---IPGHARARVFRE 163
                         |.|.| |..||.|.:.....|..|.:...:|.|.|.|   |....|..|.||
plant    83 PEPILGRPFEDIKEKYSL-GRELGRGQFGITYICTEISSGKNFACKSILKRKLIRTKDREDVRRE 146

  Fly   164 VETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLD 228
            ::..|:..|...|:::...:||.:..:||.|...||.|..:|.:...:||..|::||:.:...:.
plant   147 IQIMHYLSGQPNIVEIKGAYEDRQSVHLVMELCEGGELFDKITKRGHYSEKAAAEIIRSVVKVVQ 211

  Fly   229 FLHKKGIAHRDLKPEN-ILCVKTDSLCPIKICDFDLGSGI---KFTTDISSPAATPQLLTPVGSA 289
            ..|..|:.|||||||| :|..|.::...:|..||.:...|   |...||            ||||
plant   212 ICHFMGVIHRDLKPENFLLSSKDEASSMLKATDFGVSVFIEEGKVYEDI------------VGSA 264

  Fly   290 EFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGW---NRGENCRTCQE 351
            .::||||:      ...|.|..|:||.|||.||||||.|||         |   ::|
plant   265 YYVAPEVL------KRNYGKAIDIWSAGVILYILLCGNPPF---------WAETDKG-------- 306

  Fly   352 LLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIR---MCEQEPPAS 413
             :||.|..|...|....|..:|:.||||:.|:|......|.:|..||.|||||   ....:|..|
plant   307 -IFEEILRGEIDFESEPWPSISESAKDLVRNMLKYDPKKRFTAAQVLEHPWIREGGEASDKPIDS 370

  Fly   414 KHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMD 478
            ....|.|.|:..:.:::               :|.|.:..   :::.:.:|....::    |.||
plant   371 AVLSRMKQLRAMNKLKK---------------LAFKFIAQ---NLKEEELKGLKTMF----ANMD 413

  Fly   479 AYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGG 543
              :|::      |..|.:..:    |.|...|.|::.   ..........:...|.:..|..
plant   414 --TDKS------GTITYDELK----SGLEKLGSRLTE---TEVKQLLEDADVDGNGTIDYIE--- 460

  Fly   544 F--KTLNVHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCE--TLGEDRFRRQSGSEGDEVEDD 604
            |  .|:|....:.:|...:||.|.|.|:....||:|.:...:  .:|:|...::..|   ||:.|
plant   461 FISATMNRFRVEREDNLFKAFQHFDKDNSGFISRQELETAMKEYNMGDDIMIKEIIS---EVDAD 522

  Fly   605 EDGENEDYQHY 615
            .|| :.:||.:
plant   523 NDG-SINYQEF 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	100/297 (34%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	99/295 (34%)
CPK19	NP_176386.2	STKc_CAMK	97..356	CDD:270687	98/295 (33%)
		Pkinase	98..357	CDD:278497	99/295 (34%)
		PTZ00184	393..538	CDD:185504	35/169 (21%)
		EFh	405..464	CDD:238008	13/80 (16%)
		EFh	477..537	CDD:238008	18/60 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24349
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110