DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lk6 and CDPK2

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_174807.1	Gene:	CDPK2 / 840471	AraportID:	AT1G35670	Length:	495	Species:	Arabidopsis thaliana

Alignment Length:	552	Identity:	141/552 - (25%)
Similarity:	221/552 - (40%)	Gaps:	109/552 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 MQKKRRKKRISSSL---HSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDK---IP 153
            |:.|...:|.|:::   .:...::.| |.|:.||:|.:.:...|....|...||.|.|.|   :.
plant     1 METKPNPRRPSNTVLPYQTPRLRDHY-LLGKKLGQGQFGTTYLCTEKSTSANYACKSIPKRKLVC 64

  Fly   154 GHARARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQ 218
            ......|:||::..||...|..::::...:||....::|.|...||.|..||.....|||.||.:
plant    65 REDYEDVWREIQIMHHLSEHPNVVRIKGTYEDSVFVHIVMEVCEGGELFDRIVSKGHFSEREAVK 129

  Fly   219 IIKEIASGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIK---FTTDISSPAATP 280
            :||.|...::..|..|:.||||||||.|.........:|..||.|....|   :..|:
plant   130 LIKTILGVVEACHSLGVMHRDLKPENFLFDSPKDDAKLKATDFGLSVFYKPGQYLYDV------- 187

  Fly   281 QLLTPVGSAEFMAPEVVDLFVGEAHYYDKRC-----DLWSLGVIAYILLCGYPPFSGNCGEDCGW 340
                 |||..::||||:           |:|     |:||.|||.||||.|.|||         |
plant   188 -----VGSPYYVAPEVL-----------KKCYGPEIDVWSAGVILYILLSGVPPF---------W 227

  Fly   341 NRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRM 405
            ...|:.      :|..|.:|...|....|..:|:.|||||..:|.:....|:||...|.|||| :
plant   228 AETESG------IFRQILQGKLDFKSDPWPTISEAAKDLIYKMLERSPKKRISAHEALCHPWI-V 285

  Fly   406 CEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFS-MRYDYMKERPNI 469
            .||..|       .|.|. |:.:.|    .::.||..:......||:.:..| .....:||...:
plant   286 DEQAAP-------DKPLD-PAVLSR----LKQFSQMNKIKKMALRVIAERLSEEEIGGLKELFKM 338

  Fly   470 YQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNA 534
            .....:....:.:.....|..|                      |.:......|...:.:...:.
plant   339 IDTDNSGTITFEELKAGLKRVG----------------------SELMESEIKSLMDAADIDNSG 381

  Fly   535 SAIYPNSGGF--KTLNVHEEDDDDEGLEAFGHIDDDDEWSRSRREYQQQCETLG------EDRFR 591
            :..|   |.|  .||::::.:.::..:.||.:.|.|.....:..|.|..|...|      :|..:
plant   382 TIDY---GEFLAATLHMNKMEREENLVAAFSYFDKDGSGYITIDELQSACTEFGLCDTPLDDMIK 443

  Fly   592 RQSGSEGDEVEDDEDGENEDYQHYKHYWRELD 623
                    |::.|.||: .|:..:....|:.|
plant   444 --------EIDLDNDGK-IDFSEFTAMMRKGD 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	96/298 (32%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	96/296 (32%)
CDPK2	NP_174807.1	STKc_CAMK	25..283	CDD:270687	95/296 (32%)
		Pkinase	26..284	CDD:278497	96/296 (32%)
		PTZ00184	320..462	CDD:185504	26/175 (15%)
		EFh	332..391	CDD:238008	9/83 (11%)
		EFh	404..463	CDD:238008	14/67 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24349
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.110