DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and Dclk1

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_038959175.1	Gene:	Dclk1 / 83825	RGDID:	68437	Length:	756	Species:	Rattus norvegicus

Alignment Length:	507	Identity:	157/507 - (30%)
Similarity:	234/507 - (46%)	Gaps:	64/507 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KSGTAASAAAAK-----ASNNNNNNHPRGSGDSGIRSGSGISCSNTDNSCSQSQSDGQN--ELTR 62
            :.||..|...::     ||.::.|..| ||..|..|||...|.|.|.....:.|...|:  ..|.
  Rat   292 RRGTTKSPGPSRRSKSPASTSSVNGTP-GSQLSTPRSGKSPSPSPTSPGSLRKQRISQHGGSSTS 355

  Fly    63 YSSEDV-SGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGE 126
            .||..| |..:.::.|...:     ||.|.....:..||::........:|..|.||: |..:|:
  Rat   356 LSSTKVCSSMDENDGPGEGD-----ELGRRHSLQRGWRREESDEGFQIPATITERYKV-GRTIGD 414

  Fly   127 GAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFR-EVETFHHCQGHLGILQLIEFFEDDEKFY 190
            |.:|.|:.|:...|..|||:|:|.|.....:..:.: ||......: |..|:.|||..:...:.|
  Rat   415 GNFAVVKECIERSTAREYALKIIKKSKCRGKEHMIQNEVSILRRVK-HPNIVLLIEEMDVPTELY 478

  Fly   191 LVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILCVK-TDSLC 254
            ||.|.:.||.|...|.....::|.:||.::..:||.:.:||...|.|||:||||:|..: .|...
  Rat   479 LVMELVKGGDLFDAITSTSKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDGSK 543

  Fly   255 PIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVI 319
            .:|:.||.|      .|.:..|     |.|..|:..::|||:    :.|.. |..:.|:|:.|||
  Rat   544 SLKLGDFGL------ATIVDGP-----LYTVCGTPTYVAPEI----IAETG-YGLKVDIWAAGVI 592

  Fly   320 AYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLL 384
            .||||||:|||.|: |:|            ||:||:.|..|...||...|.:|||.||:||:.:|
  Rat   593 TYILLCGFPPFRGS-GDD------------QEVLFDQILMGQVDFPSPYWDNVSDSAKELINMML 644

  Fly   385 VKKASNRLSAEAVLNHPWIR---MCEQEPPASKHGRRHKALQT---PSNIRRNHQSAREISQFAE 443
            :.....|.||..||.|||:.   :.|.|...|..|:..|...|   ||:      :|..:|..|.
  Rat   645 LVNVDQRFSAVQVLEHPWVNDDGLPENEHQLSVAGKIKKHFNTGPKPSS------TAAGVSVIAT 703

  Fly   444 SAMAVKRVVL-----QHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPP 490
            :|:..:|.|.     |....||......|.:...|:.|..:.|:...:|..|
  Rat   704 TALDKERQVFRRRRNQDVRGRYKAQPAPPELNSESEDYSPSSSETVRSPNSP 755

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	103/289 (36%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	102/287 (36%)
Dclk1	XP_038959175.1	DCX1_DCLK1	55..143	CDD:340660
		DCX2	182..265	CDD:340589
		STKc_DCKL1	399..666	CDD:271085	105/297 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920