DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lk6 and CDPK9

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_197748.1	Gene:	CDPK9 / 832424	AraportID:	AT5G23580	Length:	490	Species:	Arabidopsis thaliana

Alignment Length:	512	Identity:	136/512 - (26%)
Similarity:	215/512 - (41%)	Gaps:	99/512 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 GEILGEGAYASVQTCVNIYTDLEYAVKVIDK---IPGHARARVFREVETFHHCQGHLGILQLIEF 182
            |::||:|.:.:...|.:..|..:.|.|.|.|   :.......|.||::..||...:..::::...
plant    25 GQVLGQGQFGTTFLCTHKQTGQKLACKSIPKRKLLCQEDYDDVLREIQIMHHLSEYPNVVRIESA 89

  Fly   183 FEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILC 247
            :||.:..:||.|...||.|..||.:...:||.||:::||.|...::..|..|:.||||||||.|.
plant    90 YEDTKNVHLVMELCEGGELFDRIVKRGHYSEREAAKLIKTIVGVVEACHSLGVVHRDLKPENFLF 154

  Fly   248 VKTDSLCPIKICDFDLGSGIKFTTDISSPAATP-----QLLTPVGSAEFMAPEVVDLFVGEAHYY 307
            ..:|....:|..||.|           |...||     :|   ||||.::||||:.      .:|
plant   155 SSSDEDASLKSTDFGL-----------SVFCTPGEAFSEL---VGSAYYVAPEVLH------KHY 199

  Fly   308 DKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDV 372
            ...||:||.|||.||||||:|||         |...|..      :|..|.:|...|....|..:
plant   200 GPECDVWSAGVILYILLCGFPPF---------WAESEIG------IFRKILQGKLEFEINPWPSI 249

  Fly   373 SDEAKDLISNLLVKKASNRLSAEAVLNHPWI---RMCEQEPPASKHGRRHKALQTPSNIRRNHQS 434
            |:.|||||..:|......||:|..||.||||   ::...:|.......|.|.....:.:::
plant   250 SESAKDLIKKMLESNPKKRLTAHQVLCHPWIVDDKVAPDKPLDCAVVSRLKKFSAMNKLKK---- 310

  Fly   435 AREISQFAESAMAVKRVVLQHFS-MRYDYMKERPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRS 498
                       ||: ||:.:..| .....:||...:....::....:.:            ...|
plant   311 -----------MAL-RVIAERLSEEEIGGLKELFKMIDTDKSGTITFEE------------LKDS 351

  Fly   499 QRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGGF--KTLNVHEEDDDDEGLEA 561
            .|...|.|         |..:.....|:: :...:.:..|   |.|  .|:::::.:.::..:.|
plant   352 MRRVGSEL---------MESEIQELLRAA-DVDESGTIDY---GEFLAATIHLNKLEREENLVAA 403

  Fly   562 FGHIDDDDEWSRSRREYQQQCETLGEDRFRRQSGSEGDEVEDDEDGENE---DYQHY 615
            |...|.|.....:..|.||..:..|      .:.|..||:..|.|.:|:   ||..:
plant   404 FSFFDKDASGYITIEELQQAWKEFG------INDSNLDEMIKDIDQDNDGQIDYGEF 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	98/289 (34%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	98/289 (34%)
CDPK9	NP_197748.1	STKc_CAMK	21..279	CDD:270687	97/288 (34%)
		Pkinase	22..280	CDD:278497	98/289 (34%)
		PTZ00184	316..458	CDD:185504	29/170 (17%)
		EFh	328..387	CDD:238008	11/83 (13%)
		EFh	400..459	CDD:238008	16/61 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24349
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020