DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and CAMK4

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001310303.1	Gene:	CAMK4 / 814	HGNCID:	1464	Length:	473	Species:	Homo sapiens

Alignment Length:	591	Identity:	141/591 - (23%)
Similarity:	220/591 - (37%)	Gaps:	175/591 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 ELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQL 179
            :.:::..| ||.||.:.|..|....|...||:||:.|.......|.  |:...... .|..|::|
Human    44 DFFEVESE-LGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRT--EIGVLLRL-SHPNIIKL 104

  Fly   180 IEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPEN 244
            .|.||...:..||.|.:.||.|..||.|...:||.:|:..:|:|...:.:||:.||.||||||||
Human   105 KEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPEN 169

  Fly   245 ILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDK 309
            :|........|:||.||.|...::....:.:...||         .:.|||::     ....|..
Human   170 LLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTP---------GYCAPEIL-----RGCAYGP 220

  Fly   310 RCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSD 374
            ..|:||:|:|.||||||:.||....|:...:.|..||            |.:|..|  .|.:||.
Human   221 EVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNC------------EYYFISP--WWDEVSL 271

  Fly   375 EAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREIS 439
            .||||:..|:|.....||:....|.|||:                               ..:.:
Human   272 NAKDLVRKLIVLDPKKRLTTFQALQHPWV-------------------------------TGKAA 305

  Fly   440 QFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPAS 504
            .|.....|.|:  ||.|:.|           :..:|.:.|.                     .||
Human   306 NFVHMDTAQKK--LQEFNAR-----------RKLKAAVKAV---------------------VAS 336

  Fly   505 SLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGGFKTLNVHEEDDDDEGLEAFGHIDDDD 569
            |..   |..||.||    |.:.|..|||:.|.|               .|.:|.::|.
Human   337 SRL---GSASSSHG----SIQESHKASRDPSPI---------------QDGNEDMKAI------- 372

  Fly   570 EWSRSRREYQQQCETLGEDRFRRQSGSEGDEVEDD-----EDGENEDYQHYKHYWRELDEEEGDD 629
                                      .||::::.|     ..|...:....    :.|::.:|.|
Human   373 --------------------------PEGEKIQGDGAQAAVKGAQAELMKV----QALEKVKGAD 407

  Fly   630 YLYEQQQRVDDKFGEEEFEDEPKEETQADNLKLSKAYVEQVGETNVEKSKPQDDNGGYI------ 688
            ...|:..::..|..|:..        :..:|:|.:...|:..:|..|.:.|::..|...
Human   408 INAEEAPKMVPKAVEDGI--------KVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVP 464

  Fly   689 REDLIM 694
            ::|:|:
Human   465 QQDVIL 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	94/287 (33%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	94/285 (33%)
CAMK4	NP_001310303.1	STKc_CaMKIV	42..335	CDD:270987	104/387 (27%)
		Pkinase	46..300	CDD:278497	94/285 (33%)
		Autoinhibitory domain	305..321		5/17 (29%)
		PP2A-binding	306..323		6/18 (33%)
		Calmodulin-binding. /evidence=ECO:0000255	322..341		6/53 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	341..368		12/45 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	445..473		5/26 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920