DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and Dclk2

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001344389.1	Gene:	Dclk2 / 70762	MGIID:	1918012	Length:	772	Species:	Mus musculus

Alignment Length:	522	Identity:	149/522 - (28%)
Similarity:	226/522 - (43%)	Gaps:	105/522 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PKSGTAASAAAAKASNNNNNNHPRGSGD-SGIR--SGSGISCSNTDNSCSQSQSDGQNELTR-YS 64
            |.:||.:|..:...|..::::.|...|. .|::  |..|.|.||.         :|..||.| .|
Mouse   335 PVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAQGRSSSNV---------NGGPELDRCLS 390

  Fly    65 SEDVSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAY 129
            .|.|:||..||                                  |....|.|:: |:::|:|.:
Mouse   391 PEGVNGNRCSE----------------------------------SFPLLEKYRI-GKVIGDGNF 420

  Fly   130 ASVQTCVNIYTDLEYAVKVIDKIPGHARARVF-REVETFHHCQGHLGILQLIEFFEDDEKFYLVF 193
            |.|:.||:.||..|:|:|:|||.....:..:. .||......: |..|:.|:|..|.....:||.
Mouse   421 AVVKECVDRYTGKEFALKIIDKAKCCGKEHLIENEVSILRRVK-HPNIIMLVEEMETATDLFLVM 484

  Fly   194 EKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENIL-CVKTDSLCPIK 257
            |.:.||.|...|.....::|.:.|.::..:|:.|.:||...|.|||:||||:| |...|....:|
Mouse   485 ELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHSLSIVHRDIKPENLLVCEYPDGTKSLK 549

  Fly   258 ICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYI 322
            :.||.|      .|.:..|     |.|..|:..::|||:    :.|.. |..:.|:|:.|||.||
Mouse   550 LGDFGL------ATVVEGP-----LYTVCGTPTYVAPEI----IAETG-YGLKVDVWAAGVITYI 598

  Fly   323 LLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKK 387
            ||||:|||           |.||  ..||.||:.|..|...||...|.:::|.||:|||.:|...
Mouse   599 LLCGFPPF-----------RSEN--NLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVN 650

  Fly   388 ASNRLSAEAVLNHPWIRMCEQEPPASKHGRRH-----KALQTPSN-IRRNHQSAREISQFAESAM 446
            ...|.:|..:|:|||:     ...||:.....     |..|..:| :.:.:.:...:|....:|:
Mouse   651 VEARCTAGEILSHPWV-----SDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTAL 710

  Fly   447 AVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYS--DENYNPKPPGHYTRNRSQRNPASSLCGY 509
            ..:.   |.|..:......||:..|.|.....|..  ....:|:|||         .||:|.|..
Mouse   711 DKEG---QIFCSKLCQDSSRPSREQTSPVPPSAQEAPPPLESPRPPG---------PPATSGCDL 763

  Fly   510 GG 511
            .|
Mouse   764 AG 765

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	100/289 (35%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	99/287 (34%)
Dclk2	NP_001344389.1	DCX	67..157	CDD:214711
		DCX	191..279	CDD:214711
		PKc_like	407..665	CDD:328722	99/288 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920