DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and CAMK1D

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_705718.1	Gene:	CAMK1D / 57118	HGNCID:	19341	Length:	385	Species:	Homo sapiens

Alignment Length:	364	Identity:	118/364 - (32%)
Similarity:	170/364 - (46%)	Gaps:	62/364 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 RKKRISSSLHSSTFQELYKL--TGEILGEGAYASVQTCVNIYTDLEYAVKVIDK--IPGHARA-- 158
            |:...|||......:::.|:  ..|.||.||::.|.......|...:|||.|.|  :.|...:
Human     3 RENGESSSSWKKQAEDIKKIFEFKETLGTGAFSEVVLAEEKATGKLFAVKCIPKKALKGKESSIE 67

  Fly   159 ---RVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQII 220
               .|.|:::       |..|:.|.:.:|.....|||.:.::||.|..||.|...::|.:||.:|
Human    68 NEIAVLRKIK-------HENIVALEDIYESPNHLYLVMQLVSGGELFDRIVEKGFYTEKDASTLI 125

  Fly   221 KEIASGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDL----GSGIKFTTDISSPAATPQ 281
            :::...:.:||:.||.||||||||:|....|....|.|.||.|    |.|     |:.|
Human   126 RQVLDAVYYLHRMGIVHRDLKPENLLYYSQDEESKIMISDFGLSKMEGKG-----DVMS------ 179

  Fly   282 LLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENC 346
              |..|:..::||||:     ....|.|..|.||:||||||||||||||           ..||
Human   180 --TACGTPGYVAPEVL-----AQKPYSKAVDCWSIGVIAYILLCGYPPF-----------YDEN- 225

  Fly   347 RTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPP 411
               ...|||.|.:..:.|....|.|:||.|||.|.||:.|..:.|.:.|....||||     ...
Human   226 ---DSKLFEQILKAEYEFDSPYWDDISDSAKDFIRNLMEKDPNKRYTCEQAARHPWI-----AGD 282

  Fly   412 ASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKR 450
            .:.:...|:::.  :.||:|...::....|  :|.||.|
Human   283 TALNKNIHESVS--AQIRKNFAKSKWRQAF--NATAVVR 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	103/300 (34%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	103/298 (35%)
CAMK1D	NP_705718.1	STKc_CaMKI_delta	12..312	CDD:271070	110/348 (32%)
		Autoinhibitory domain. /evidence=ECO:0000250	279..319		10/48 (21%)
		Calmodulin-binding. /evidence=ECO:0000250	299..320		6/21 (29%)
		Nuclear export signal. /evidence=ECO:0000250	318..324		118/364 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	360..385
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920