DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and mknk1

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_005156011.1	Gene:	mknk1 / 555974	ZFINID:	ZDB-GENE-080220-11	Length:	490	Species:	Danio rerio

Alignment Length:	457	Identity:	210/457 - (45%)
Similarity:	283/457 - (61%)	Gaps:	60/457 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SCSNTDNSCSQSQSDGQNELTRYSSEDVS------GNESSEAPNMTEVERQAELNRHKEEMQKKR 99
            ||..:.:.....:.:.:..|:|..| .||      |.|||:..::|            :...:::
Zfish    28 SCQISSSILGSGKVESRGSLSRVPS-TVSQTSTGLGMESSQPISIT------------DPSSRRK 79

  Fly   100 RKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREV 164
            :|:|.:....:..|.:||:||.|:||:||||.||.||::....|||||:|:|..||:|:||||||
Zfish    80 KKRRRAGDSFTGKFCDLYRLTDELLGQGAYAKVQGCVSLQNGTEYAVKIIEKNAGHSRSRVFREV 144

  Fly   165 ETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDF 229
            ||.:.|||:..||:||:|||||..|||||||:.||.:|:.||....|.|.|||:::::||:.|||
Zfish   145 ETLYQCQGNKNILELIQFFEDDSCFYLVFEKLRGGSILTHIQSRKYFDEREASRVVRDIANALDF 209

  Fly   230 LHKK-----------------------------GIAHRDLKPENILCVKTDSLCPIKICDFDLGS 265
            ||.|                             ||||||||||||||..||.:.|:|||||||||
Zfish   210 LHNKGKHCMCTLQPTNHESASVCLFTLVSIFPTGIAHRDLKPENILCEYTDKVSPVKICDFDLGS 274

  Fly   266 GIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPF 330
            |:|..: ..:|..||:|.||.||||:||||||::|..||.:|||||||||||||.||||.|.|||
Zfish   275 GVKLNS-ACTPITTPELTTPCGSAEYMAPEVVEVFTDEASFYDKRCDLWSLGVILYILLSGSPPF 338

  Fly   331 SGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAE 395
            :|:||.:|||.|||.||:||..|||.||||.:.|.:..|..:|.:||||||.|||:.|:.||||.
Zfish   339 TGHCGTNCGWERGETCRSCQNNLFERIQEGKYEFSDGVWTQISADAKDLISRLLVRDATLRLSAA 403

  Fly   396 AVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRY 460
            .||.|||::....|          :.|.||..::|| .|.::::|||..|:|..|.:.|....:.
Zfish   404 QVLQHPWVQGNAPE----------RVLPTPRVLQRN-CSTKDLTQFAAEAIAFNRQLSQQEEEQE 457

  Fly   461 DY 462
            |:
Zfish   458 DF 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	179/316 (57%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	178/314 (57%)
mknk1	XP_005156011.1	PKc_like	95..412	CDD:304357	180/317 (57%)
mknk1	XP_005156011.1	S_TKc	102..411	CDD:214567	175/309 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596898
Domainoid	1	1.000	394	1.000	Domainoid score	I735
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37838
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002552
OrthoInspector	1	1.000	-	-		otm26129
orthoMCL	1	0.900	-	-		OOG6_106134
Panther	1	1.100	-	-	LDO	PTHR24349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5431
SonicParanoid	1	1.000	-	-		X1678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.870