DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and stk33

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_031755965.1	Gene:	stk33 / 549733	XenbaseID:	XB-GENE-940061	Length:	480	Species:	Xenopus tropicalis

Alignment Length:	489	Identity:	136/489 - (27%)
Similarity:	215/489 - (43%)	Gaps:	84/489 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    87 ELNRHKEEMQKKRRKKRISSSLHS-----STFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAV 146
            |.|| |...|..|.....|...|:     :..|::|.. |:.||:|::..|....:..|..::|:
Frog     8 EANR-KMPSQWSRDNSAESKVPHTRMDDEAAIQQIYTF-GKKLGQGSFGVVIEATHKETATKWAM 70

  Fly   147 KVI--DKIPGHARARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHI 209
            |.:  :|....|...:.|||......: |..|:.|.|.||..::.|||.|...||.|...:....
Frog    71 KKVNREKAGSSAVKLLEREVSILKRVK-HDHIIHLEEVFETPKRMYLVTELCEGGELREILHRKK 134

  Fly   210 CFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILCVKTDS------LCPIKICDFDLG---S 265
            |.||.|...:|:.:.|.:.:||:|||.|||||.||||....|.      :..||:.||.|.   .
Frog   135 CLSEAETRHVIRSLGSAIAYLHRKGIVHRDLKLENILVKSNDGADNEELILNIKVTDFGLAVQKG 199

  Fly   266 GIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPF 330
            |:.....:.|...||         .:|||||::     .|.|.::||:||.|||.|:||.|.|||
Frog   200 GVGSENMLQSTCGTP---------IYMAPEVIN-----DHDYSQQCDIWSTGVIMYMLLSGNPPF 250

  Fly   331 SGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAE 395
            ...               .:|.|||.|:.|...|.:|.|..:|:.|||::..||....::|::|.
Frog   251 MAG---------------SEEKLFEDIRRGELKFSDAVWQGISNAAKDVLQRLLKVDPAHRITAN 300

  Fly   396 AVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRR-----NHQSAREISQFAESAMAVKRVVLQH 455
            .:|::|||.            .....:|.|:|:..     .:..|.|:....|::..:.   |.|
Frog   301 ELLDNPWIT------------GETTLVQRPTNVLELMNAWKNLDADELDHLDENSNGLS---LAH 350

  Fly   456 FSMRYDYMKERPNIYQP------SQAYMDAYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMS 514
            . :....::||.:   |      |:..:|..:|.: :.||.....:...::..:|||.....:..
Frog   351 L-IDIPTVEERAS---PASSNGTSEMGLDTETDSS-SSKPSTPTNQVTKKKTVSSSLTSRTVKKK 410

  Fly   515 SMHGQRANSRRSSRNAS-----RNASAIYPNSGG 543
            |...:.|:|..::.|.|     |.:.....:|||
Frog   411 SSTLKPASSPSTNGNTSPCSNTRRSPETQEHSGG 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	97/298 (33%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	97/296 (33%)
stk33	XP_031755965.1	PKc_like	40..308	CDD:419665	97/298 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010