DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and Mknk1

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_006238756.1	Gene:	Mknk1 / 500526	RGDID:	1559603	Length:	446	Species:	Rattus norvegicus

Alignment Length:	422	Identity:	211/422 - (50%)
Similarity:	282/422 - (66%)	Gaps:	28/422 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 EEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHAR 157
            ::.:||:||.|.:.|| ...|:::|:||.|:|||||||.||..|::.:..|||||:|:|..||:|
  Rat    46 DKRRKKKRKTRATDSL-PGKFEDVYQLTSELLGEGAYAKVQGAVSLQSGKEYAVKIIEKQAGHSR 109

  Fly   158 ARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKE 222
            :||||||||.:.|||:..||:||||||||.:|||||||:.||.:|:.||:...|:|.|||:::::
  Rat   110 SRVFREVETLYQCQGNRNILELIEFFEDDTRFYLVFEKLQGGSILAHIQKRKHFNELEASRVVRD 174

  Fly   223 IASGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVG 287
            :|:.|||||.|||||||||||||||...:.:.|:||||||||||:|.... .:|..||:|.||.|
  Rat   175 VATALDFLHTKGIAHRDLKPENILCESPEKVSPVKICDFDLGSGVKLNNS-CTPITTPELTTPCG 238

  Fly   288 SAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQEL 352
            |||:||||||::|..||.:||||||||||||:.||:|.|||||.|:||.||||:|||.||.||..
  Rat   239 SAEYMAPEVVEVFRDEATFYDKRCDLWSLGVVLYIMLSGYPPFVGHCGADCGWDRGEVCRMCQNK 303

  Fly   353 LFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGR 417
            ||||||||.:.||:.:|..:|.|||||||.|||:.|..||||..||.|||::  .|.|
  Rat   304 LFESIQEGKYEFPDKDWAHISTEAKDLISKLLVRDAKQRLSAAQVLQHPWVQ--GQAP------- 359

  Fly   418 RHKALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSD 482
             .:.|.||..::|| .|..:::.||..|:|:.|.:.||         |...:.:..:|..:....
  Rat   360 -ERGLPTPQVLQRN-SSTMDLTLFAAEAIALNRQLSQH---------EENELAEEHEALAEGLCS 413

  Fly   483 ENYNPKPPGHYTRNRS------QRNPASSLCG 508
            ...:|.......|.|:      :.|..|:..|
  Rat   414 MKLSPPSKSRLARRRALAHAGREANSCSTPAG 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	179/287 (62%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	179/285 (63%)
Mknk1	XP_006238756.1	STKc_Mnk1	67..355	CDD:271076	180/288 (63%)
Mknk1	XP_006238756.1	S_TKc	74..354	CDD:214567	176/280 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354569
Domainoid	1	1.000	385	1.000	Domainoid score	I774
eggNOG	1	0.900	-	-		E1_KOG0607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37838
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002552
OrthoInspector	1	1.000	-	-		otm44902
orthoMCL	1	0.900	-	-		OOG6_106134
Panther	1	1.100	-	-	LDO	PTHR24349
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1678
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.740