DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and mknk1

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_031755885.1	Gene:	mknk1 / 493413	XenbaseID:	XB-GENE-979969	Length:	421	Species:	Xenopus tropicalis

Alignment Length:	405	Identity:	212/405 - (52%)
Similarity:	280/405 - (69%)	Gaps:	24/405 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 KKRRKKRISSSLHSST--FQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARAR 159
            |:|:|||.:.::.|.|  |.:||:||.|:|||||||.||.||::....:||||:::|..||:|:|
Frog    18 KRRKKKRRTRAMESFTGKFADLYRLTDELLGEGAYAKVQGCVSLQNGKDYAVKIVEKKAGHSRSR 82

  Fly   160 VFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIA 224
            |||||||.:.|||:..||:||||.|||.:|||||||:.||.:||.||:...|:|.|||:::|:||
Frog    83 VFREVETLYQCQGNKNILELIEFCEDDARFYLVFEKLRGGSILSHIQKRKHFNEREASKVVKDIA 147

  Fly   225 SGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSA 289
            |.|||||.|||||||||||||||...|.:.|:||||||||||:|..: ..:|..||:|.||.|||
Frog   148 SALDFLHTKGIAHRDLKPENILCEFKDKVSPVKICDFDLGSGVKLNS-ACTPITTPELTTPCGSA 211

  Fly   290 EFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLF 354
            |:||||||::|..||.:|||||||||||||.||:|.|||||.||||.||||:|||.||.||..||
Frog   212 EYMAPEVVEVFTEEATFYDKRCDLWSLGVILYIMLSGYPPFVGNCGADCGWDRGEMCRVCQNKLF 276

  Fly   355 ESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRH 419
            ||||||.:.|||.:|..:|:.||||||.|||:.|..||||..||.|||:   :.:.|       .
Frog   277 ESIQEGKYEFPEKDWSHISNSAKDLISKLLVRDAKERLSAAQVLQHPWL---QGDAP-------E 331

  Fly   420 KALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDEN 484
            :.|.||..::|| .|.::::.||..|:|:.|.:.||.|          ::.:..::::.......
Frog   332 RGLPTPLVLQRN-SSTKDLTIFAAEAVALNRQLSQHDS----------DLNEEHESFIHTVCSMR 385

  Fly   485 YNPKPPGHYTRNRSQ 499
            .:|.......:.|:|
Frog   386 LSPPSKSRLAKRRAQ 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	185/287 (64%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	184/285 (65%)
mknk1	XP_031755885.1	STKc_Mnk1	38..326	CDD:271076	186/291 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	389	1.000	Domainoid score	I787
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37838
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002552
OrthoInspector	1	1.000	-	-		otm47948
Panther	1	1.100	-	-	LDO	PTHR24349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5431
SonicParanoid	1	1.000	-	-		X1678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.040