DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lk6 and mylkb

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_009300538.1	Gene:	mylkb / 492576	ZFINID:	ZDB-GENE-041111-150	Length:	966	Species:	Danio rerio

Alignment Length:	659	Identity:	165/659 - (25%)
Similarity:	265/659 - (40%)	Gaps:	133/659 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EPKSGTAASAAAAKASNNNNNNHPRGSGDSGIRSGSGISCSNTDN------SCSQSQSDGQNELT 61
            :|.:|..|::...::|...:...|...|.|.::|.:....::.||      ||:.:....||.|:
Zfish   391 DPPAGIPAASDIRRSSLTLSWYGPTYDGGSIVQSYNLEIWNSVDNTWNDLTSCNSTSFHVQNLLS 455

  Fly    62 ------RYSSEDV--SGNESSE-------APNMTEVERQAE----LNRHKEEMQKKRRKKRISSS 107
                  |..:.:|  .|..|:|       |..:||.:.:.|    ::...||.:.:.|...|...
Zfish   456 DRQYKFRVRAVNVYGVGEPSAESGPIEVGAEEVTEKKEEEEVGAAVSDDDEEKEPEYRDVVIKKD 520

  Fly   108 LHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREV---ETFHH 169
            .....|.::    .:.||.|.:..|...|...:...:|.|.|.......:..|.:|:   .:.||
Zfish   521 CSVKDFYDI----EDRLGTGKFGQVFKLVEKSSKKVWAGKFIKAFSQKEKENVRQEIGIMNSLHH 581

  Fly   170 CQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRI-QEHICFSEHEASQIIKEIASGLDFLHKK 233
            .:    ::|.::.||......:|.|.|:||.|..|| .|....:|.|..:.:.:|..|:.|:||:
Zfish   582 PK----LVQCMDAFEGKSDMVMVMEMISGGELFERIVDEDFELTEREVIKYMLQIIDGVQFIHKQ 642

  Fly   234 GIAHRDLKPENILCV-KTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVV 297
            ||.|.|||||||:|: ||.|  .||:.||.|...::.:..:.....||         ||:||||:
Zfish   643 GIVHLDLKPENIMCINKTGS--KIKLIDFGLARRLEDSGSLKVLFGTP---------EFVAPEVI 696

  Fly   298 DLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHF 362
            :.   ||..|.  .|:||:|||.|||:.|..||.|:       |..|.        ..::....:
Zfish   697 NY---EAISYP--TDMWSIGVICYILVSGLSPFMGD-------NDNET--------LANVTSATW 741

  Fly   363 SFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPA---SKHGRRHKALQT 424
            .|.:..:.::||:|||.||.||.|....||:......|.|::...:...|   ||. |..|.:
Zfish   742 DFEDEAFDEISDQAKDFISRLLKKDMRARLTCAQCFEHSWLKQDTKNMEAKQLSKE-RMKKYI-- 803

  Fly   425 PSNIRRNHQ----SAREISQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDENY 485
               :||..|    :.|.||:|:...|      |.....:    |..|...:|...::::..|||:
Zfish   804 ---LRRRWQKTGNAVRAISRFSSMGM------LGGIGPK----KSSPTEEEPPAPFLESVEDENH 855

  Fly   486 NPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAIYPNSGGFKTLNVH 550
            .|..|              |.......:..:.|..|................|.:....|.....
Zfish   856 TPAAP--------------SFASVIQDVEVVEGSAARFDCKIEGCPDPEVVWYKDDQPIKETRHF 906

  Fly   551 EEDDDDEGLEAFGHI---------DDDDEWSRSRREYQQQCET---LGEDRFRRQSGSE-GDEVE 602
            :.|.:::     ||.         |||.:::         |:.   |||.....:...| ..|.|
Zfish   907 QIDYEED-----GHCSLVISEVCPDDDAKYT---------CKAVNGLGEASCTAELMVEFMQEEE 957

  Fly   603 DDEDGENED 611
            .|.:||.||
Zfish   958 GDAEGEEED 966

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	90/292 (31%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	90/290 (31%)
mylkb	XP_009300538.1	I-set	166..255	CDD:254352
		IGc2	180..245	CDD:197706
		Ig	296..394	CDD:299845	1/2 (50%)
		I-set	296..386	CDD:254352
		FN3	390..475	CDD:238020	18/83 (22%)
		PKc_like	524..782	CDD:304357	91/296 (31%)
		Pkinase	527..782	CDD:278497	90/293 (31%)
		I-set	860..950	CDD:254352	16/117 (14%)
		IGc2	873..940	CDD:197706	11/80 (14%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010