Protein Alignment Lk6 and MYLK

DIOPT Version :9

• Sequence 1: NP_651986.2
• Gene: Lk6 / 44672
• FlyBaseID: FBgn0017581
• Length: 1142
• Species: Drosophila melanogaster
• Sequence 2: XP_024309300.1
• Gene: MYLK / 4638
• HGNCID: 7590
• Length: 1924
• Species: Homo sapiens
• Alignment Length: 525
• Identity: 134/525 - (25%)
• Similarity: 232/525 - (44%)
• Gaps: 85/525 - (16%)

  Fly     3 EPKSGTAASAAAAKASNNNNNNHPRGSGDSGIRSGSGISCSNTDN-------SCSQSQSDGQNEL 60
            :|.:||..::....:|...:.......|.|.::|.| |...::.|       :|..:..:.|:.|
Human  1342 DPPAGTPCASDIRSSSLTLSWYGSSYDGGSAVQSYS-IEIWDSANKTWKELATCRSTSFNVQDLL 1405

  Fly    61 T------RYSSEDVSG-NESSEAPNMTEVERQAELNRHKEEMQKKRRKK--------RISSSLHS 110
            .      |..:.:|.| :|.|:...:|.|..:.|..:.:.|:.....|:        .|::....
Human  1406 PDHEYKFRVRAINVYGTSEPSQESELTTVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTINTEQKV 1470

  Fly   111 STFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLG 175
            |.|.::    .|.||.|.:..|...|...|...:|.|.........:..:.:|: :..:|..|..
Human  1471 SDFYDI----EERLGSGKFGQVFRLVEKKTRKVWAGKFFKAYSAKEKENIRQEI-SIMNCLHHPK 1530

  Fly   176 ILQLIEFFEDDEKFYLVFEKINGGPLLSR-IQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRD 239
            ::|.::.||:.....:|.|.::||.|..| |.|....:|.|..:.:::|:.|::::||:||.|.|
Human  1531 LVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVHLD 1595

  Fly   240 LKPENILCV-KTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLF-VG 302
            ||||||:|| ||.:  .||:.||.|...::....:.....||         ||:||||::.. :|
Human  1596 LKPENIMCVNKTGT--RIKLIDFGLARRLENAGSLKVLFGTP---------EFVAPEVINYEPIG 1649

  Fly   303 EAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEA 367
            .|      .|:||:|||.|||:.|..||.|:       |..|.        ..::....:.|.:.
Human  1650 YA------TDMWSIGVICYILVSGLSPFMGD-------NDNET--------LANVTSATWDFDDE 1693

  Fly   368 EWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGR-RHKALQTPSNIRRN 431
            .:.::||:|||.|||||.|...|||.....|.|||:....:...|.|..: |.|........::.
Human  1694 AFDEISDDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQKT 1758

  Fly   432 HQSAREISQFAESAMAVKRVVLQHFS------------MRYDYMKERPNIYQPSQAYMDAYSDEN 484
            ..:.|.|.:.:..||      :...|            :..:.::...::   |||:::|.::|.
Human  1759 GNAVRAIGRLSSMAM------ISGLSGRKSSTGSPTSPLNAEKLESEEDV---SQAFLEAVAEEK 1814

  Fly   485 YNPKP 489
            .:.||
Human  1815 PHVKP 1819

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	91/290 (31%)
		S_TKc	117..403	CDD:214567	91/288 (32%)
MYLK	XP_024309300.1	I-set	43..133	CDD:254352
		I-set	171..260	CDD:254352
		23ISL	261..422	CDD:318761
		I-set	424..514	CDD:254352
		I-set	524..610	CDD:254352
		I-set	633..722	CDD:254352
		I-set	731..819	CDD:254352
		I-set	1108..1197	CDD:254352
		Ig8_hMLCK_like	1248..1345	CDD:143239	1/2 (50%)
		FN3	1341..1433	CDD:238020	18/91 (20%)
		STKc_MLCK1	1471..1729	CDD:271093	93/294 (32%)
		I-set	1819..1909	CDD:254352	1/1 (100%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.010