DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and CaMKII

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001162833.1	Gene:	CaMKII / 43828	FlyBaseID:	FBgn0264607	Length:	531	Species:	Drosophila melanogaster

Alignment Length:	379	Identity:	115/379 - (30%)
Similarity:	177/379 - (46%)	Gaps:	67/379 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 FQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHAR--------ARVFREVETFHH 169
            |.:.|.:..| ||:||::.|:.||...|..|:|.|:|:.....||        ||:.|::.
  Fly    10 FSDNYDIKEE-LGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQKLEREARICRKLH---- 69

  Fly   170 CQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKG 234
               |..|::|.:..:::...||||:.:.||.|...|.....:||.:||..|::|...::..|:.|
  Fly    70 ---HPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVAREFYSEADASHCIQQILESVNHCHQNG 131

  Fly   235 IAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISS---PAATPQLLTPVGSAEFMAPEV 296
            :.||||||||:|.........:|:.||  |..|:...|..:   .|.||         .:::|||
  Fly   132 VVHRDLKPENLLLASKAKGAAVKLADF--GLAIEVQGDHQAWFGFAGTP---------GYLSPEV 185

  Fly   297 VDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGH 361
            :     :...|.|..|:|:.|||.||||.|||||         |:..      |..|:..|:.|.
  Fly   186 L-----KKEPYGKSVDIWACGVILYILLVGYPPF---------WDED------QHRLYSQIKAGA 230

  Fly   362 FSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPAS------------K 414
            :.:|..||..|:.|||:||:.:|....:.|::|...|.||||  |::|..||            |
  Fly   231 YDYPSPEWDTVTPEAKNLINQMLTVNPNKRITAAEALKHPWI--CQRERVASVVHRQETVDCLKK 293

  Fly   415 HGRRHK---ALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKE 465
            ...|.|   |:.|.....||..|...|::..|.:...:.......::..|.:||
  Fly   294 FNARRKLKGAILTTMLATRNFSSRSMITKKGEGSQVKESTDSSSTTLEDDDIKE 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	95/298 (32%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	95/296 (32%)
CaMKII	NP_001162833.1	STKc_CaMKII	12..303	CDD:270988	104/331 (31%)
		S_TKc	14..272	CDD:214567	95/296 (32%)
		CaMKII_AD	390..517	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.010