DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and mknk2b

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_919383.1	Gene:	mknk2b / 373121	ZFINID:	ZDB-GENE-030829-2	Length:	475	Species:	Danio rerio

Alignment Length:	477	Identity:	225/477 - (47%)
Similarity:	293/477 - (61%)	Gaps:	56/477 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QNELTRYSSEDVSG-NESSEAPNMTEVERQAELNRHKEEM----------------------QKK 98
            ||::|     :|:| :.|.:..|..|.|..::...|..|.                      .||
Zfish     3 QNKIT-----EVTGFHRSFKGQNPFETEEFSKTGSHLLESAFNFDCSARPDMPSSQPIDIPDSKK 62

  Fly    99 RRKK----RISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARAR 159
            |.||    |.:.|. |..|:::|||..|:|||||||.||||::..|..|||||:|:|.|||:|:|
Zfish    63 RNKKKKRCRATDSF-SGRFEDVYKLQDEVLGEGAYARVQTCISQITQKEYAVKIIEKRPGHSRSR 126

  Fly   160 VFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIA 224
            ||||||..:.||||..||:|:||||:::||||||||:.||.:|:.|.:...|.|.|||.:::::|
Zfish   127 VFREVEMLYQCQGHRSILELVEFFEEEDKFYLVFEKLRGGSILAHIHKRRYFGEQEASIVVQDVA 191

  Fly   225 SGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSA 289
            |.|||||.||:||||||||||||.....:.|:||||||||||||..:| |||.:||:||||.|||
Zfish   192 SALDFLHNKGMAHRDLKPENILCEHEHRISPVKICDFDLGSGIKLNSD-SSPISTPELLTPCGSA 255

  Fly   290 EFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLF 354
            |:||||||:.|..||..|||||||||||||.||:|.|||||.|.||.||||..||.|:.||.:||
Zfish   256 EYMAPEVVEAFNEEATIYDKRCDLWSLGVILYIMLSGYPPFVGRCGSDCGWENGEPCQACQNMLF 320

  Fly   355 ESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRH 419
            ||||||.:.|||.||..:|..||||||.|||:.|..||||..||.|||::           |...
Zfish   321 ESIQEGKYEFPEKEWAHISSSAKDLISKLLVRDAKKRLSAAQVLQHPWVQ-----------GGAF 374

  Fly   420 KALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDEN 484
            ..|.: ||:.:.:.|.::::.||..|:|:.|.:.|...:.....::.|.:...|...|
Zfish   375 DCLPS-SNLPQRNSSTKDLTFFAGKAVAMNRQLAQQDDLEEQQQQDSPQVITASSTSM------- 431

  Fly   485 YNPKPPGHYTRNRSQRNPASSL 506
             ...||.:  ...::|...|||
Zfish   432 -RLSPPSN--SKLAKRRQRSSL 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	184/287 (64%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	184/285 (65%)
mknk2b	NP_919383.1	PKc_like	82..369	CDD:304357	184/287 (64%)
mknk2b	NP_919383.1	S_TKc	84..369	CDD:214567	184/285 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596897
Domainoid	1	1.000	394	1.000	Domainoid score	I735
eggNOG	1	0.900	-	-		E1_KOG0607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002552
OrthoInspector	1	1.000	-	-		otm26129
orthoMCL	1	0.900	-	-		OOG6_106134
Panther	1	1.100	-	-	O	PTHR24349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5431
SonicParanoid	1	1.000	-	-		X1678
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730