DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and mknk2a

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_997888.1	Gene:	mknk2a / 334167	ZFINID:	ZDB-GENE-030131-6099	Length:	472	Species:	Danio rerio

Alignment Length:	425	Identity:	214/425 - (50%)
Similarity:	281/425 - (66%)	Gaps:	55/425 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 QNELTRYSSEDVSG-NESSEAPNMTEVERQAELNRHKEEM---------------------QKKR 99
            ||::|     :|:| :.|.:..|..:.:...:.:.|.|..                     .|||
Zfish     3 QNKIT-----EVTGFHRSFKGQNPFKTDEFIDSDSHLESSFILERSTRPAMPSSQPIDIPDAKKR 62

  Fly   100 RKK----RISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARV 160
            .||    |.:.|. |..|:::|||..|:|||||||.||||:|:.|:.|||||:|:|.|||:|:||
Zfish    63 NKKKKRCRATDSF-SGRFEDVYKLQNEVLGEGAYAVVQTCINLITNKEYAVKIIEKRPGHSRSRV 126

  Fly   161 FREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIAS 225
            |||||..:.||||..||:|:|:||:::||||||||:.||.:|:.|.....|:|.|||.::::|||
Zfish   127 FREVEMLYQCQGHRNILELVEYFEEEDKFYLVFEKLRGGSILTHIHRRQHFNEQEASIVVQDIAS 191

  Fly   226 GLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAE 290
            .|||||.||:||||||||||||..:|.:.|:||||||||||||..:| |||.:||:||||.||||
Zfish   192 ALDFLHNKGMAHRDLKPENILCEHSDRISPVKICDFDLGSGIKLNSD-SSPISTPELLTPCGSAE 255

  Fly   291 FMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFE 355
            :||||||:.|..||..|||||||||||||.||:|.|||||.|.||.||||:.||.|:.||.:|||
Zfish   256 YMAPEVVEAFNEEASIYDKRCDLWSLGVILYIMLSGYPPFVGRCGTDCGWDWGEPCQACQSMLFE 320

  Fly   356 SIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHK 420
            |||||.:.|||.:|..:|..|||||:.|||:.|.:||||..||.|||::.|
Zfish   321 SIQEGKYEFPEKDWAHISPAAKDLITKLLVRDAKDRLSAAQVLQHPWVKGC-------------- 371

  Fly   421 ALQTPSNIRRN--HQ---SAREISQFAESAMAVKR 450
               .|:.:..:  ||   ||::::.||..|:|:.|
Zfish   372 ---APNTVSASILHQRGGSAQDLTFFAGQAVAMNR 403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	184/287 (64%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	184/285 (65%)
mknk2a	NP_997888.1	STKc_Mnk2	81..368	CDD:271075	184/287 (64%)
mknk2a	NP_997888.1	S_TKc	83..368	CDD:214567	184/285 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596896
Domainoid	1	1.000	394	1.000	Domainoid score	I735
eggNOG	1	0.900	-	-		E1_KOG0607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002552
OrthoInspector	1	1.000	-	-		otm26129
orthoMCL	1	0.900	-	-		OOG6_106134
Panther	1	1.100	-	-	O	PTHR24349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5431
SonicParanoid	1	1.000	-	-		X1678
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.730