DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and Dclk3

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001178729.1	Gene:	Dclk3 / 316023	RGDID:	1309232	Length:	807	Species:	Rattus norvegicus

Alignment Length:	446	Identity:	120/446 - (26%)
Similarity:	202/446 - (45%)	Gaps:	75/446 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NNNNN-----------NHPRG---------SGDSGIRSGSGISCSNTDNSC--------SQSQSD 55
            |||::           :||:|         .|...:..|:..:..::.::|        .:.|..
  Rat   386 NNNSDKKESRGSEAQESHPQGVAKAQKDLMEGLPAVEEGAVDARRDSRHTCRIKHAAWLRREQQA 450

  Fly    56 GQNELTRYSSEDVSGNESSEAPNM---TEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELY 117
            ...:|.|...|:.......::..:   ..:|::::....:...::...:|...:.:.|:..::.|
  Rat   451 EPPQLPRTRGEEKEAEHEKKSGGLGGRRMLEKESKTKPEENRPERPSGRKLRPTGIISADVEKHY 515

  Fly   118 KLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQLIEF 182
            .: |.::|:|.:|.|:.|.:..|...||:|:|||.....:..:............|..|::|.|.
  Rat   516 DI-GRVIGDGNFAIVKECKHRETRQAYAMKIIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEV 579

  Fly   183 FEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILC 247
            :|.:.:.||:.|.:.||.|...|.|.:.|.|.:|:.:|.::...|..:|.|.|.||||||||:|.
  Rat   580 YETEAEIYLIMEYVQGGDLFDAIIESVKFPEPDAAVMITDLCKALVHMHDKKIVHRDLKPENLLV 644

  Fly   248 VKT-DSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRC 311
            .:. |....:|:.||.|...:           ...:.|..|:..::|||::     ....|....
  Rat   645 QRNEDKSTTLKLADFGLAKHV-----------VRPIFTVCGTPTYVAPEIL-----SEKGYGLEV 693

  Fly   312 DLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEA 376
            |:|:.|||.||||||:|||             .:....|:.||..||.|.|.|....|.::||.|
  Rat   694 DMWAAGVILYILLCGFPPF-------------RSPERDQDELFNIIQLGQFEFLSPYWDNISDAA 745

  Fly   377 KDLISNLLVKKASNRLSAEAVLNHPWIRMC---------EQEPPASKHGR---RHK 420
            |||:.||||.....|.:|..||:||||.|.         ::|.|:|: ||   :||
  Rat   746 KDLVRNLLVVDPKKRYTAHQVLHHPWIGMVGHPSTVNPQKEESPSSE-GRFQSQHK 800

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	94/288 (33%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	94/286 (33%)
Dclk3	NP_001178729.1	UBQ	92..177	CDD:294102
		PKc_like	514..771	CDD:304357	93/286 (33%)
		S_TKc	515..772	CDD:214567	94/286 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010