DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lk6 and Mylk

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001099344.2	Gene:	Mylk / 288057	RGDID:	1310915	Length:	1961	Species:	Rattus norvegicus

Alignment Length:	670	Identity:	157/670 - (23%)
Similarity:	275/670 - (41%)	Gaps:	149/670 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 EPKSGTAASAAAAKASNNNNNNHPRGSGDSGIRSGSGISCSNTD------------NSCSQSQSD 55
            :|.:||..      ||:..:::.......|....||.:...|.:            .:|..:..:
  Rat  1375 DPPAGTPC------ASDIRSSSLTLSWYGSSYDGGSAVQSYNVEIWDTEDKVWTELATCRSTSFN 1433

  Fly    56 GQNELT------RYSSEDVSG-NESSEAPNMTEVERQAELNRHKEEMQKKRRKK-----RISSSL 108
            .|:.|.      |..:.:|.| :|.|:...:|.|..:.|..:.:.|:.....|:     |..:..
  Rat  1434 VQDLLPDREYKFRVRAVNVYGTSEPSQESELTAVGEKPEEPKDEVEVSDDDEKEPEVDYRTVTVN 1498

  Fly   109 HSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGH 173
            ......::|.:. |.||.|.:..|...|...|...:|.|.........:..:.:|: :..:|..|
  Rat  1499 TEQKVSDVYDIE-ERLGSGKFGQVFRLVEKRTGKIWAGKFFKAYSAKEKENIRQEI-SIMNCLHH 1561

  Fly   174 LGILQLIEFFEDDEKFYLVFEKINGGPLLSR-IQEHICFSEHEASQIIKEIASGLDFLHKKGIAH 237
            ..::|.::.||:.....:|.|.::||.|..| |.|....:|.|..:.:::|:.|::::||:||.|
  Rat  1562 PKLVQCVDAFEEKANIVMVLEIVSGGELFERIIDEDFELTERECIKYMRQISEGVEYIHKQGIVH 1626

  Fly   238 RDLKPENILCV-KTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLF- 300
            .|||||||:|| ||.:  .||:.||.|...::....:.....||         ||:||||::..
  Rat  1627 LDLKPENIMCVNKTGT--RIKLIDFGLARRLENAGSLKVLFGTP---------EFVAPEVINYEP 1680

  Fly   301 VGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFP 365
            :|.|      .|:||:|||.|||:.|..||.|:       |..|.        ..::....:.|.
  Rat  1681 IGYA------TDMWSIGVICYILVSGLSPFMGD-------NDNET--------LANVTSATWDFD 1724

  Fly   366 EAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGR-RHKALQTPSNIR 429
            :..:.::|::|||.|||||.|...|||.....|.|||:....:...|.|..: |.|........:
  Rat  1725 DEAFDEISEDAKDFISNLLKKDMKNRLDCTQCLQHPWLMKDTKNMEAKKLSKDRMKKYMARRKWQ 1789

  Fly   430 RNHQSAREISQFAESAMAVKRVVLQHFSMR------------YDYMKERPNIYQPSQAYMDAYSD 482
            :...:.|.|.:.:..||      :...|.|            .:.::...::   |||:::|.::
  Rat  1790 KTGNAVRAIGRLSSMAM------ISGLSGRKSSTGSPTSPINAEKLESEEDV---SQAFLEAVAE 1845

  Fly   483 ENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRSSRNASRNASAI--YPNSG--G 543
            |..:.||  ::::....             :..:.|          :|:|....|  ||:..  .
  Rat  1846 EKPHVKP--YFSKTIRD-------------LEVVEG----------SAARFDCKIEGYPDPEVVW 1885

  Fly   544 FKTLNVHEEDDDDEGLEAFGH--IDDDDEWSRS--------RREYQQQCE---TLGE-------- 587
            ||         ||:.:....|  ||.|::.:.|        ..:.:..|:   :|||
  Rat  1886 FK---------DDQSIRESRHFQIDYDEDGNCSLIISDVCGDDDAKYTCKAVNSLGEATCTAELI 1941

  Fly   588 -DRFRRQSGSEGDEVEDDED 606
             :......|.||.|.|::|:
  Rat  1942 VETMEEGEGEEGGEEEEEEE 1961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	91/290 (31%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	91/288 (32%)
Mylk	NP_001099344.2	I-set	42..132	CDD:254352
		Ig	64..129	CDD:143165
		I-set	165..254	CDD:254352
		Ig	183..251	CDD:143165
		23ISL	255..408	CDD:293226
		I-set	410..500	CDD:254352
		Ig	427..497	CDD:143165
		I-set	510..596	CDD:254352
		IGc2	523..586	CDD:197706
		I-set	619..708	CDD:254352
		Ig	636..704	CDD:143165
		I-set	717..805	CDD:254352
		Ig	720..805	CDD:299845
		I-set	1141..1230	CDD:254352
		IGc2	1154..1220	CDD:197706
		Ig	1281..1378	CDD:299845	1/2 (50%)
		I-set	1281..1370	CDD:254352
		FN3	1374..1465	CDD:238020	17/95 (18%)
		STKc_MLCK1	1504..1762	CDD:271093	91/291 (31%)
		Pkinase	1507..1762	CDD:278497	91/288 (32%)
		I-set	1852..1942	CDD:254352	20/123 (16%)
		IGc2	1865..1932	CDD:197706	16/85 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010