DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and MKNK2

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_951009.1	Gene:	MKNK2 / 2872	HGNCID:	7111	Length:	465	Species:	Homo sapiens

Alignment Length:	386	Identity:	209/386 - (54%)
Similarity:	271/386 - (70%)	Gaps:	15/386 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 GNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQT 134
            |.:.|..|:| ...:..::...|:..:||:|.:...|  .|..|:::|:|..::|||||:|.|||
Human    39 GLQCSARPDM-PASQPIDIPDAKKRGKKKKRGRATDS--FSGRFEDVYQLQEDVLGEGAHARVQT 100

  Fly   135 CVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGG 199
            |:|:.|..|||||:|:|.|||.|:|||||||..:.||||..:|:||||||::::|||||||:.||
Human   101 CINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGG 165

  Fly   200 PLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLG 264
            .:||.|.:...|:|.|||.:::::||.|||||.|||||||||||||||...:.:.|:||||||||
Human   166 SILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLG 230

  Fly   265 SGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPP 329
            ||||...| .||.:||:||||.||||:||||||:.|..||..|||||||||||||.||||.||||
Human   231 SGIKLNGD-CSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPP 294

  Fly   330 FSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSA 394
            |.|.||.||||:|||.|..||.:||||||||.:.||:.:|..:|..||||||.|||:.|..||||
Human   295 FVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSA 359

  Fly   395 EAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMAVKRVVLQH 455
            ..||.|||::.|..|          ..|.||..::|| ..|::::.||..|:|:.|.:.||
Human   360 AQVLQHPWVQGCAPE----------NTLPTPMVLQRN-SCAKDLTSFAAEAIAMNRQLAQH 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	182/287 (63%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	182/285 (64%)
MKNK2	NP_951009.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	23..72		8/33 (24%)
		Nuclear localization signal	60..66		1/5 (20%)
		STKc_Mnk2	81..368	CDD:271075	182/287 (63%)
		S_TKc	83..368	CDD:214567	182/285 (64%)
		Staurosporine binding	160..162		1/1 (100%)
		MAP kinase binding. /evidence=ECO:0000250	444..448
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160505
Domainoid	1	1.000	388	1.000	Domainoid score	I797
eggNOG	1	0.900	-	-		E1_KOG0607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002552
OrthoInspector	1	1.000	-	-		otm40762
orthoMCL	1	0.900	-	-		OOG6_106134
Panther	1	1.100	-	-	O	PTHR24349
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.740