DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and Dclk3

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_766516.2	Gene:	Dclk3 / 245038	MGIID:	3039580	Length:	790	Species:	Mus musculus

Alignment Length:	429	Identity:	122/429 - (28%)
Similarity:	192/429 - (44%)	Gaps:	68/429 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NNNNNNHPRGS---------GDSGIRSGSGISCSNTDNSCSQS---------QSDGQNELTRYSS 65
            :.:.::||:|:         |...:..|. |.....|....:|         |.....:|.|...
Mouse   396 SESQDSHPQGAPKAQKDLVEGPPAVEEGP-IDMRREDRHTCRSKHAAWLRREQQAEPPQLPRTRG 459

  Fly    66 EDVSGNESSEAPNMTEVERQAELNRHKEEMQKKR------RKKRISSSLHSSTFQELYKLTGEIL 124
            |:.......:...:.  ||:|.....|.::::||      ||.| ...:.|:..::.|.: |.::
Mouse   460 EEKQAEHEKKPGGLG--ERRAPEKESKRKLEEKRPERPSGRKPR-PKGIISADVEKHYDI-GGVI 520

  Fly   125 GEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQLIEFFEDDEKF 189
            |:|.:|:|:.|.:..|...||:|:|||.....:..:............|..|::|.|.:|.:.:.
Mouse   521 GDGNFATVKECRHRETKQAYAMKMIDKSQLKGKEDIVDSEILIIQSLSHPNIVKLHEVYETEAEI 585

  Fly   190 YLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILCVKT-DSL 253
            ||:.|.:.||.|...|.|::.|.|.||:.:|.::...|..:|.|.|.|||:||||:|..:. |..
Mouse   586 YLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKNIVHRDVKPENLLVQRNEDKS 650

  Fly   254 CPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGV 318
            ..:|:.||.|...:           ...:.|..|:..::|||::     ....|....|:|:.||
Mouse   651 ITLKLADFGLAKYV-----------VRPIFTVCGTPTYVAPEIL-----SEKGYGLEVDMWAAGV 699

  Fly   319 IAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNL 383
            |.||||||:|||             .:....|:.||..||.|.|.|....|.::||.||||:.||
Mouse   700 ILYILLCGFPPF-------------RSPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNL 751

  Fly   384 LVKKASNRLSAEAVLNHPWIRMC---------EQEPPAS 413
            |......|.:||.||.||||.|.         ::|.|.|
Mouse   752 LEVDPKKRYTAEQVLQHPWIEMVGHTNTGNSQKEESPNS 790

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	94/288 (33%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	94/286 (33%)
Dclk3	NP_766516.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		UBQ	92..177	CDD:294102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..290
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..506		21/113 (19%)
		PKc_like	513..770	CDD:304357	93/286 (33%)
		S_TKc	514..771	CDD:214567	94/286 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010