DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and zyg-8

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_499571.2	Gene:	zyg-8 / 176639	WormBaseID:	WBGene00006993	Length:	802	Species:	Caenorhabditis elegans

Alignment Length:	409	Identity:	110/409 - (26%)
Similarity:	179/409 - (43%)	Gaps:	69/409 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SSEDVSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGE------ 122
            :||:.....|..:.||....|::.:....|.:    |..|..|.:.....|.|..|..|
Worm   426 ASEEHKSVGSGTSSNMRRTSRRSTMPNRNESL----RHDRSGSVIPDQDQQRLPPLLDEKFQLVR 486

  Fly   123 ILGEGAYASVQTCVN-IYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQLIE----- 181
            ::|:|..|.|...:: ...|...|:|||      ||..|   :...|..:..|.|||.|:
Worm   487 LIGDGNTAVVYEVIDKTNNDDRKAMKVI------ARENV---IGKEHLIEMELAILQKIDHTFIV 542

  Fly   182 -----FFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLK 241
                 :|.|| .:||..|.|..|.|...::......|.:|.:::..:...|:::|:.||.|||:|
Worm   543 QLYDHWFVDD-SYYLSLELIEMGDLFEHLRIVRRVPERDAVRMMTCLGQALEYIHELGIVHRDVK 606

  Fly   242 PENILCVKTD-SLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAH 305
            .||:|.||.: ....:|:.||.|.:        ..|.....|.|..|:..::||||::. .|
Worm   607 LENLLIVKDEFGELGVKLADFGLAA--------EMPKDFGVLSTICGTPTYVAPEVLNK-TG--- 659

  Fly   306 YYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWH 370
             |..:.|:|:.|||.|.:|.|:|||..:.|.             ::.||.:|..|.||||...|.
Worm   660 -YGCKVDIWAAGVILYAILVGFPPFQSSDGS-------------EQDLFSAIMSGEFSFPSPSWD 710

  Fly   371 DVSDEAKDLISNLLVKKASNRLSAEAVLNHPW-IRMCEQEPPASKHGRRHKALQTPSNIRRNHQS 434
            |||...:.||..|:.....:|.||..:||..| :.:.:.:|...:..  |:.:|:..::....::
Worm   711 DVSWSVRHLIMCLIHTDPFHRYSAGELLNDEWMVNLGDVDPEYEEWA--HRFVQSKMHVEEEQET 773

  Fly   435 ARE--------ISQFAESA 445
            ..|        :.:.:|||
Worm   774 PYEYYTSRRTSMDELSESA 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	92/306 (30%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	91/304 (30%)
zyg-8	NP_499571.2	DCX	206..298	CDD:214711
		DCX	335..423	CDD:214711
		STKc_DCKL	481..742	CDD:270997	88/296 (30%)
		S_TKc	482..743	CDD:214567	88/296 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010