DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and Mknk2

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_067437.2	Gene:	Mknk2 / 17347	MGIID:	894279	Length:	459	Species:	Mus musculus

Alignment Length:	458	Identity:	220/458 - (48%)
Similarity:	294/458 - (64%)	Gaps:	35/458 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 GQNELTRYSSEDVSGNESSE-------APNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTF 113
            |||......|.|::.:..|:       .|:|.. .:..::...|:..:||:|.:...|  .|..|
Mouse    18 GQNPFELAFSLDLAQHRDSDFSPQCEARPDMPS-SQPIDIPDAKKRGRKKKRCRATDS--FSGRF 79

  Fly   114 QELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVFREVETFHHCQGHLGILQ 178
            :::|:|..::|||||:|.||||||:.|:.|||||:|:|..||.|:|||||||..:.||||..:|:
Mouse    80 EDVYQLQEDVLGEGAHARVQTCVNLITNQEYAVKIIEKQLGHIRSRVFREVEMLYQCQGHRNVLE 144

  Fly   179 LIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPE 243
            ||||||::::|||||||:.||.:||.|.....|:|.|||.:::::||.|||||.|||||||||||
Mouse   145 LIEFFEEEDRFYLVFEKMRGGSILSHIHRRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPE 209

  Fly   244 NILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYD 308
            ||||...:.:.|:||||||||||||...| .||.:||:||||.||||:||||||:.|..||..||
Mouse   210 NILCEHPNQVSPVKICDFDLGSGIKLNGD-CSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYD 273

  Fly   309 KRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVS 373
            |||||||||||.||||.|||||.|:||.||||:|||.|..||.:||||||||.:.||:.:|..:|
Mouse   274 KRCDLWSLGVILYILLSGYPPFVGHCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWSHIS 338

  Fly   374 DEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREI 438
            ..||||||.|||:.|..||||..||.|||::.|..|          ..|.||..::|| ..|:::
Mouse   339 FAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPE----------NTLPTPLVLQRN-SCAKDL 392

  Fly   439 SQFAESAMAVKRVVLQHFSMRYDYMKERPNIYQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPA 503
            :.||..|:|:.|.:.|   ...|..:::|.:.:.:...:..        .||..  ...:||...
Mouse   393 TSFAAEAIAMNRQLAQ---CEEDAGQDQPVVIRATSRCLQL--------SPPSQ--SKLAQRRQR 444

  Fly   504 SSL 506
            :||
Mouse   445 ASL 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	182/287 (63%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	182/285 (64%)
Mknk2	NP_067437.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..67		4/30 (13%)
		Nuclear localization signal. /evidence=ECO:0000250	60..66		1/5 (20%)
		PKc_like	81..368	CDD:389743	182/287 (63%)
		Staurosporine binding. /evidence=ECO:0000250	160..162		1/1 (100%)
		MAP kinase binding	438..442		1/3 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850852
Domainoid	1	1.000	386	1.000	Domainoid score	I800
eggNOG	1	0.900	-	-		E1_KOG0607
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002552
OrthoInspector	1	1.000	-	-		otm42836
orthoMCL	1	0.900	-	-		OOG6_106134
Panther	1	1.100	-	-	O	PTHR24349
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5431
SonicParanoid	1	1.000	-	-		X1678
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.730