DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and DCLK2

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	NP_001035351.4	Gene:	DCLK2 / 166614	HGNCID:	19002	Length:	783	Species:	Homo sapiens

Alignment Length:	551	Identity:	152/551 - (27%)
Similarity:	233/551 - (42%)	Gaps:	129/551 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PKSGTAASAAAAKASNNNNNNHPRGSGD-SGIR--SGSGISCSNTDNSCSQSQSDGQNELTR-YS 64
            |.:||.:|..:...|..::::.|...|. .|::  |..|.|.||.         :|..||.| .|
Human   337 PVNGTPSSQLSTPKSTKSSSSSPTSPGSFRGLKQISAHGRSSSNV---------NGGPELDRCIS 392

  Fly    65 SEDVSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAY 129
            .|.|:||..||                                  |||..|.||: |:::|:|.:
Human   393 PEGVNGNRCSE----------------------------------SSTLLEKYKI-GKVIGDGNF 422

  Fly   130 ASVQTCVNIYTDLEYAVKVIDKIPGHARARVF-REVETFHHCQGHLGILQLIEFFEDDEKFYLVF 193
            |.|:.|::..|..|:|:|:|||.....:..:. .||......: |..|:.|:|..|...:.:||.
Human   423 AVVKECIDRSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVK-HPNIIMLVEEMETATELFLVM 486

  Fly   194 EKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENIL-CVKTDSLCPIK 257
            |.:.||.|...|.....::|.:.|.::..:|:.|.:||...|.|||:||||:| |...|....:|
Human   487 ELVKGGDLFDAITSSTKYTERDGSAMVYNLANALRYLHGLSIVHRDIKPENLLVCEYPDGTKSLK 551

  Fly   258 ICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYI 322
            :.||.|      .|.:..|     |.|..|:..::|||:    :.|.. |..:.|:|:.|||.||
Human   552 LGDFGL------ATVVEGP-----LYTVCGTPTYVAPEI----IAETG-YGLKVDIWAAGVITYI 600

  Fly   323 LLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKK 387
            ||||:|||           |.||  ..||.||:.|..|...||...|.:::|.||:|||.:|...
Human   601 LLCGFPPF-----------RSEN--NLQEDLFDQILAGKLEFPAPYWDNITDSAKELISQMLQVN 652

  Fly   388 ASNRLSAEAVLNHPWIRMCEQEPPASKHGRRH-----KALQTPSN-IRRNHQSAREISQFAESAM 446
            ...|.:|..:|:|||:     ...||:.....     |..|..:| :.:.:.:...:|....:|:
Human   653 VEARCTAGQILSHPWV-----SDDASQENNMQAEVTGKLKQHFNNALPKQNSTTTGVSVIMNTAL 712

  Fly   447 AVKRVVLQHFSMRYDYMKERP-------------NIYQPSQAYMDAYSDENYNPKPPGHYTRNRS 498
            ..:.   |.|..::.....||             .|..|.:|.......|:..|.||
Human   713 DKEG---QIFCSKHCQDSGRPGMEPISPVPPSVEEIPVPGEAVPAPTPPESPTPHPP-------- 766

  Fly   499 QRNPASSLCGYGGRMSSMHGQRANSRRSSRN 529
               ||:.           .|:||.:.|..|:
Human   767 ---PAAP-----------GGERAGTWRRHRD 783

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	99/289 (34%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	98/287 (34%)
DCLK2	NP_001035351.4	DCX	67..157	CDD:214711
		DCX	192..280	CDD:214711
		STKc_DCKL2	409..667	CDD:271086	98/288 (34%)
		S_TKc	411..668	CDD:214567	98/287 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920