DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Lk6 and Camk2a

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_006525604.1	Gene:	Camk2a / 12322	MGIID:	88256	Length:	489	Species:	Mus musculus

Alignment Length:	302	Identity:	99/302 - (32%)
Similarity:	149/302 - (49%)	Gaps:	36/302 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 SSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVID--KIPGHARARVFREVETFH 168
            :::..:.|.|.|:|..| ||:||::.|:.||.:....|||.|:|:  |:......::.||...
Mouse     2 ATITCTRFTEEYQLFEE-LGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARI-- 63

  Fly   169 HCQ--GHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLH 231
             |:  .|..|::|.:...::...||:|:.:.||.|...|.....:||.:||..|::|...:...|
Mouse    64 -CRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCH 127

  Fly   232 KKGIAHRDLKPENILCVKTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEV 296
            :.|:.||||||||:|.........:|:.||.|.        |.............|:..:::|||
Mouse   128 QMGVVHRDLKPENLLLASKLKGAAVKLADFGLA--------IEVEGEQQAWFGFAGTPGYLSPEV 184

  Fly   297 VDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGH 361
            :     ....|.|..|||:.|||.||||.|||||         |:..      |..|::.|:.|.
Mouse   185 L-----RKDPYGKPVDLWACGVILYILLVGYPPF---------WDED------QHRLYQQIKAGA 229

  Fly   362 FSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWI 403
            :.||..||..|:.||||||:.:|....|.|::|...|.||||
Mouse   230 YDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWI 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	96/291 (33%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	95/289 (33%)
Camk2a	XP_006525604.1	STKc_CaMKII	11..302	CDD:270988	98/293 (33%)
Camk2a	XP_006525604.1	CaMKII_AD	357..484	CDD:285524
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010