DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and camk1g

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_004910791.1	Gene:	camk1g / 100494644	XenbaseID:	XB-GENE-6085002	Length:	733	Species:	Xenopus tropicalis

Alignment Length:	853	Identity:	202/853 - (23%)
Similarity:	321/853 - (37%)	Gaps:	217/853 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 HKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGH 155
            ||||......||:.::...:..|.       |:||.||::.|....:..|...||:|.|.|:...
Frog    24 HKEEEDGSIWKKQTNNIRETFVFM-------EVLGSGAFSEVYLVKHRSTGQHYALKCIKKVNSS 81

  Fly   156 ARARVFREVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQII 220
            ....:..|:......: |..|:.|.:.:|....||||.:.::||.|..||.|...::|.:||.:|
Frog    82 RDKSLENEIAVLKRIK-HENIVTLEDIYESSSHFYLVMQLVSGGELFDRILERGVYTEKDASNVI 145

  Fly   221 KEIASGLDFLHKKGIAHRDLKPENILCVKTDSLCPIKICDFDLG----SGIKFTTDISSPAATPQ 281
            :::.|.:.:||..||.||||||||:|.:..|....|.|.||.|.    :||
Frog   146 RQVLSAVKYLHDNGIVHRDLKPENLLYLTPDENSKIMITDFGLSKMEENGI-------------- 196

  Fly   282 LLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENC 346
            :.|..|:..::||||:     ....|.|..|.||:|||.||||||||||               .
Frog   197 MSTACGTPGYVAPEVL-----AQKPYSKAVDCWSIGVITYILLCGYPPF---------------Y 241

  Fly   347 RTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPP 411
            ...:..|||.|:||.:.|....|.|:|..|||.||.||.|.:..|.:.|..|.||||
Frog   242 EETESRLFEKIREGAYEFESPFWDDISKSAKDFISCLLEKDSKKRYNCEKALKHPWI-------- 298

  Fly   412 ASKHGRRHKALQTPSNIRRNHQSAREIS-----QFAES----AMAVKRVVLQHFSMRYDYMKERP 467
                         ..|...:....|.:|     .||:|    |.....||.....:..:..:...
Frog   299 -------------AGNTALHRDIYRSVSIQIKKNFAKSKWKQAFNAATVVYHMKKLHMNNSQTSA 350

  Fly   468 NIYQPSQAYMDAYSDENYNPKPPGHYTRNRSQRNPASSLCGYGGRMSSMHGQRANSRRS--SRNA 530
            |:  |:....||     ..|..|.  .:|..:||....|..:.|..:.| ..|:.:.:|  :.|.
Frog   351 NV--PTIKVSDA-----TRPNTPN--VKNTEERNNVEILKLHPGVSNGM-PVRSGTAKSCGTINV 405

  Fly   531 SRNASAIYPNSGGFKTLNVHE--EDDDDEGLEA-FGHIDDDDEWSRSRREYQQQCETLGEDRFRR 592
            .||:.        ..|::|||  ....:..|.: ||....::..::|    |.|...|..:....
Frog   406 ERNSC--------LGTVSVHEPCTSKSNNALPSHFGQPQSEERKNQS----QNQSTELNSNSHML 458

  Fly   593 QSGSEGDEVEDDEDGENEDYQHYKHYWRELDEEEGDDYLYEQQQRVDDKFGEEEFEDEPKEETQA 657
            ..|     |:.:..|..:
Frog   459 SRG-----VQSNNPGSRK----------------------------------------------- 471

  Fly   658 DNLKLSKAYVEQVG-ETNVEKSKPQDDNGGYIREDLIMDNMDMK--KNTQQSEFAKLTIMRNDAQ 719
               .|||...:... :|:.:...|.:.|...:.:|   |::..|  .:|:.|: |.:|:..|..
Frog   472 ---MLSKNATQNCATQTSPDHHMPMEKNQSCMMKD---DHLHRKSSSSTKGSQ-ASVTVSVNKP- 528

  Fly   720 TEENKIMQQQDEEKKEEKQQDDVDGAK---------------KQGPSSDISATTITDNNKLQTPV 769
                   .|:|...||:||  ::...|               .:.|.|.:..|..|::...::.|
Frog   529 -------AQKDSNTKEQKQ--NILSTKNISHSLDLPSPPVHNSESPKSSLRKTPSTNSPSKKSAV 584

  Fly   770 MTTTHINNWQTGDAIEDDDVKLLDSISDLNEKLPEIYETANIVVNSA---------AVPAASTPA 825
            ..:..|::.|.....:...|::     .|:.|:|    :.|||..::         ..|..||..
Frog   585 PKSISISSSQKPPPSQKSPVQV-----TLSPKIP----SENIVAQTSVQDHLDRRNTSPKKSTLD 640

  Fly   826 AS--ATRPPTDNPEEDDSNVTKPTTTAEGTTMQTTFGMSA---EEEKPVALSHTA----GHHSKT 881
            .:  .|..|...|.:..:...|....:....:..|.|||:   |:.||::.:.:.    ||..:.
Frog   641 YNTLCTDMPQCRPLDLSNGPFKTDKISASANVYVTNGMSSETYEKGKPISCTESGLVKKGHKKQN 705

  Fly   882 GRTVNFAP 889
            ......||
Frog   706 FLNAVTAP 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	100/291 (34%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	100/289 (35%)
camk1g	XP_004910791.1	STKc_CaMKI_gamma	40..324	CDD:271068	108/346 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920