DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and dclk3

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_017950468.2	Gene:	dclk3 / 100493379	XenbaseID:	XB-GENE-983282	Length:	793	Species:	Xenopus tropicalis

Alignment Length:	325	Identity:	108/325 - (33%)
Similarity:	161/325 - (49%)	Gaps:	38/325 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   115 ELYKLTGEILGEGAYASVQTCVNIYTDLEYAVKVIDKIPGHARARVF-REVETFHHCQGHLGILQ 178
            |.|...|..:|:|.:|.|:.|.....:.|||:|:|||.....:..:. .||....|. .|..|::
Frog   498 ESYYEIGRTIGDGNFAVVKVCRPWNENQEYAMKIIDKSKLRGKEDIIENEVRIIKHL-SHPNIVK 561

  Fly   179 LIEFFEDDEKFYLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPE 243
            |...:|.:::.||:.|.|.||.|...|.|.|.|:||:|:.::.::...|.::|.|.|.|||||||
Frog   562 LFSDYETEKEIYLILEYIRGGDLFDVITESIKFTEHDAALMLIDLCEALKYIHSKHIVHRDLKPE 626

  Fly   244 NILCV-KTDSLCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYY 307
            |:|.. ..|....:|:.||.|           :..||..:.|..|:..::|||::     ....|
Frog   627 NLLVQHNPDGSKSLKLADFGL-----------AIYATGPIFTVCGTPTYVAPEIL-----SEKGY 675

  Fly   308 DKRCDLWSLGVIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDV 372
            ..:.|:|:.|||.||||||:|||.         :...|    ||.||:.||.|.:.|....|..:
Frog   676 GLKVDMWATGVILYILLCGFPPFR---------SPDRN----QEELFQIIQSGEYEFLPPYWDHI 727

  Fly   373 SDEAKDLISNLLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSARE 437
            |:|.|||||.|||.....|.||:.||.|.|:....|.      ..|:...:...||.|:.::.::
Frog   728 SEEVKDLISKLLVLNPEIRYSAKCVLQHSWVTSRGQT------NSRNLQREVTVNIERHFRNRQK 786

Fly 438 437
Frog 787 786

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	102/289 (35%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	101/287 (35%)
dclk3	XP_017950468.2	DCX_DCLK3	87..171	CDD:340528
dclk3	XP_017950468.2	STKc_DCKL3	500..757	CDD:271087	101/286 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920