DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and dclk2

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_012811056.1	Gene:	dclk2 / 100487296	XenbaseID:	XB-GENE-960488	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	403	Identity:	124/403 - (30%)
Similarity:	186/403 - (46%)	Gaps:	80/403 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PKSGTAASAAAAKASNNNNNNHPRGSGD-SGIRSGSGISCSNTDNSCSQSQSDGQNELTRYSSED 67
            |.:||.:|..:...|..::.:.|...|. .|:|...  .|.:|.|         .|.|.. |.|.
Frog   330 PVNGTPSSQLSTPKSTKSSCSSPTSPGSFRGLRIPP--HCGSTSN---------VNGLLN-SPEG 382

  Fly    68 VSGNESSEAPNMTEVERQAELNRHKEEMQKKRRKKRISSSLHSSTFQELYKLTGEILGEGAYASV 132
            ::||:.::|                                  |...|.||: |:::|:|.:|.|
Frog   383 LNGNKFTDA----------------------------------SIILEKYKI-GKVIGDGNFAVV 412

  Fly   133 QTCVNIYTDLEYAVKVIDKIPGHARARVF-REVETFHHCQGHLGILQLIEFFEDDEKFYLVFEKI 196
            :.||...|..|:|:|:|||.....:..:. .||......: |..|:.|||..:...:.|||.|.:
Frog   413 KECVERSTGKEFALKIIDKAKCCGKEHLIENEVSILRQVK-HPNIIMLIEEMDTTAELYLVMELV 476

  Fly   197 NGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENIL-CVKTDSLCPIKICD 260
            .||.|...|.....::|.:||.::..:||.:.:||...|.|||:||||:| |...|....:|:.|
Frog   477 KGGDLFDAITSSTKYTERDASAMVYNLASAMKYLHGLHIVHRDIKPENLLVCEYPDKTKSLKLGD 541

  Fly   261 FDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLGVIAYILLC 325
            |.|      .|.:..|     |.|..|:..::|||:    :.|.. |..:.|:|:.|||.|||||
Frog   542 FGL------ATVVDGP-----LYTVCGTPTYVAPEI----IAETG-YGLKVDIWAAGVITYILLC 590

  Fly   326 GYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISNLLVKKASN 390
            |:|||           |.||  ..||.||:.|..|...||...|.:::|.||:|||.:|......
Frog   591 GFPPF-----------RSEN--NLQEDLFDQILIGKLEFPSPYWDNITDSAKELISCMLQVNVEE 642

  Fly   391 RLSAEAVLNHPWI 403
            |.:||.:|:|||:
Frog   643 RYTAEQILSHPWV 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	103/289 (36%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	102/287 (36%)
dclk2	XP_012811056.1	DCX1_DCLK2	70..154	CDD:340661
		DCX2	193..276	CDD:340589
		STKc_DCKL2	396..654	CDD:271086	102/288 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010