DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Lk6 and dclk3

DIOPT Version :9

Sequence 1:	NP_651986.2	Gene:	Lk6 / 44672	FlyBaseID:	FBgn0017581	Length:	1142	Species:	Drosophila melanogaster
Sequence 2:	XP_009292709.1	Gene:	dclk3 / 100333376	ZFINID:	ZDB-GENE-081104-224	Length:	721	Species:	Danio rerio

Alignment Length:	459	Identity:	124/459 - (27%)
Similarity:	211/459 - (45%)	Gaps:	74/459 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 SSEDVSGNESSEAPNMTEVERQAELNRHKEE-MQKKRRKKRISSSLHSSTFQELYKLTGEILGEG 127
            ::|.::.|..| ||...::|..:|.:.:|:| :.|........:.:.....:..| :.|.::|:|
Zfish   291 TAEKLTANNKS-APQTQDLETISEHDANKQETVLKDDNVPPDGAEVSLEDIERCY-IMGRVVGDG 353

  Fly   128 AYASVQTC-VNIYTDLEYAVKVID--KIPGHARARVFREVETFHHCQGHLGILQLIEFFEDDEKF 189
            .:|.|:.| |...|: .:|:|::|  |:.|... .|..|:......: |..::||......|...
Zfish   354 NFAVVRECRVRGLTE-TFAMKIVDNAKLQGRGH-MVQNEIALLRSLE-HPRLIQLFRSHHTDTHV 415

  Fly   190 YLVFEKINGGPLLSRIQEHICFSEHEASQIIKEIASGLDFLHKKGIAHRDLKPENILCVK--TDS 252
            ||:.|.::||.|...|.:...|:|..|:.::::|:..|:::|.|.|||||:||||:|..:  ..|
Zfish   416 YLLMELVSGGDLFDAITQSGRFTEPSAACMVRDISQALEYIHDKSIAHRDIKPENLLVQRHGNGS 480

  Fly   253 LCPIKICDFDLGSGIKFTTDISSPAATPQLLTPVGSAEFMAPEVVDLFVGEAHYYDKRCDLWSLG 317
            | .:|:.||.|...:|           ..:.|..|:..::|||:    :.|.. |....|:|::|
Zfish   481 L-NLKLADFGLALVVK-----------EPVFTVCGTPTYVAPEI----LAETG-YGVGVDVWAMG 528

  Fly   318 VIAYILLCGYPPFSGNCGEDCGWNRGENCRTCQELLFESIQEGHFSFPEAEWHDVSDEAKDLISN 382
            ||.::||.|:|||.         :...|    ||.||..||:|...|....|.:||:.||.|:.:
Zfish   529 VILFVLLSGFPPFR---------SPDRN----QEELFRLIQKGEVHFLSPYWDNVSEGAKALVRS 580

  Fly   383 LLVKKASNRLSAEAVLNHPWIRMCEQEPPASKHGRRHKALQTPSNIRRNHQSAREISQFAESAMA 447
            ||......||:|...|...||:....:   ..|....||..:.:..|..|:.:|::    |:|.:
Zfish   581 LLEVNPKKRLTASQTLQDDWIQHATTQ---KDHKGAIKATDSTAERRNQHKLSRQV----ENAES 638

  Fly   448 VKR-VVLQHFSMRYDYMKERPNI-----------------YQPSQAYM---DAYSDENYN----- 486
            .|. .|..|.:..::..|..|:|                 .|.:..|.   |..:|:.||
Zfish   639 TKHSPVTFHTAQIHENSKCVPDINTTDRNQQIQETHSIQSKQQNSCYEEEDDTTTDQKYNTDQHK 703

  Fly   487 PKPP 490
            |:.|
Zfish   704 PEKP 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Lk6	NP_651986.2	STKc_Mnk	115..403	CDD:270992	90/292 (31%)
Lk6	NP_651986.2	S_TKc	117..403	CDD:214567	90/290 (31%)
dclk3	XP_009292709.1	UBQ	84..>156	CDD:294102
		STKc_DCKL	343..600	CDD:270997	90/290 (31%)
		S_TKc	344..601	CDD:214567	90/290 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330091at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010