DRSC/TRiP Functional Genomics Resources

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Protein Alignment cwo and BHLHE40

DIOPT Version :9

Sequence 1:NP_524775.1 Gene:cwo / 44669 FlyBaseID:FBgn0259938 Length:698 Species:Drosophila melanogaster
Sequence 2:NP_003661.1 Gene:BHLHE40 / 8553 HGNCID:1046 Length:412 Species:Homo sapiens


Alignment Length:603 Identity:113/603 - (18%)
Similarity:171/603 - (28%) Gaps:287/603 - (47%)


- Green bases have known domain annotations that are detailed below.


  Fly    55 RRNKTSRQD-PLSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLK--- 115
            :|::.|::. .|.||:|||:||||:|.|:|.|..|:|...:....|.:||..::|:.::|:|   
Human    44 KRSEDSKETYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALT 108

  Fly   116 HLQSECQQKESDYRSGYMDCMKEAAKFLYDVHMQDFCHRLLGRLQEHIDEMFKTDCYKSTRSCHM 180
            :|..:.|||....:||..                  ...|.||..|...|||          |  
Human   109 NLIDQQQQKIIALQSGLQ------------------AGELSGRNVETGQEMF----------C-- 143

  Fly   181 PDNVSASSGSPHQAYHPPLCHLRDMLATSASDV-EHSQDHNDVKDLSFRNHLNQLQRSQQAAAAA 244
                   ||                ..|.|.:| ::...|.:.:||.....:..|.|        
Human   144 -------SG----------------FQTCAREVLQYLAKHENTRDLKSSQLVTHLHR-------- 177

  Fly   245 AVAAAAVAVANGSSPASNAGVDSKVPLTNGGGTGGAPPAADNVPSNSTGSGSAAACAGGNSNSSG 309
             |.:..:.                      |||...|  :|..|.........::.|.| |...|
Human   178 -VVSELLQ----------------------GGTSRKP--SDPAPKVMDFKEKPSSPAKG-SEGPG 216

  Fly   310 SNSSNAASSTICPPAGGSCPAKVTPLAAHQQPHQAPVITSTAPHHHHHHTDSSHHDFESSREPIL 374
            .|                |               .|||..|..|.....:.|.            
Human   217 KN----------------C---------------VPVIQRTFAHSSGEQSGSD------------ 238

  Fly   375 HTDTSNMHSPPPRDLLLQQHPHLAHSHHTQDSLMSVRMRNYSESSHEIEHNNNYKYKNHIKERFV 439
             |||.:                                 .|...|.          |..::    
Human   239 -TDTDS---------------------------------GYGGESE----------KGDLR---- 255

  Fly   440 HELHDEETSSEHCPVAAHLQSDHSHLQALSEH----SKDGTEPEIAPIMAKKRKLAEAAANGEIP 500
                    |.:.|     .:|||.....:.|.    .::..||.     .||.::          
Human   256 --------SEQPC-----FKSDHGRRFTMGERIGAIKQESEEPP-----TKKNRM---------- 292

  Fly   501 LEVHTESSNAGASSANRLDKPSPSFNFSDIKDIKAELHNGNSNSSPLLAKLSAVAAAGGQLSTPS 565
                            :|......|..||:            .|||.|                 
Human   293 ----------------QLSDDEGHFTSSDL------------ISSPFL----------------- 312

  Fly   566 STTAPLPPRHTFTVPIFALHGQGNYYVPLNVDYNALVPFLNGMDLLEKSY--TSMPVVHP-ININ 627
               .|.|.:..|.:|.:.:......|:|                :|||.:  ||:||::| :|.:
Human   313 ---GPHPHQPPFCLPFYLIPPSATAYLP----------------MLEKCWYPTSVPVLYPGLNAS 358

  Fly   628 V----NFM-PSSPSASLL 640
            .    :|| |...||.||
Human   359 AAALSSFMNPDKISAPLL 376

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cwoNP_524775.1 HLH 66..118 CDD:306515 21/54 (39%)
ORANGE 126..168 CDD:128787 8/41 (20%)
BHLHE40NP_003661.1 Essential for interaction with ARNTL/BMAL1, E-box binding and repressor activity against the CLOCK-ARNTL/BMAL1 heterodimer 1..139 34/112 (30%)
bHLH-O_DEC1 40..129 CDD:381592 30/102 (29%)
Necessary for interaction with RXRA and repressor activity against RXRA. /evidence=ECO:0000269|PubMed:19786558 75..79 1/3 (33%)
ORANGE 140..184 CDD:128787 15/87 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..303 36/280 (13%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140978
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG4304
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.740

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