Protein Alignment cwo and BHLHE41

DIOPT Version :9

• Sequence 1: NP_524775.1
• Gene: cwo / 44669
• FlyBaseID: FBgn0259938
• Length: 698
• Species: Drosophila melanogaster
• Sequence 2: NP_110389.1
• Gene: BHLHE41 / 79365
• HGNCID: 16617
• Length: 482
• Species: Homo sapiens
• Alignment Length: 441
• Identity: 99/441 - (22%)
• Similarity: 155/441 - (35%)
• Gaps: 137/441 - (31%)

  Fly    55 RRNKTSRQDPLSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQS 119
            :|:.|.....|.||:|||:||||:|.|:|.|..|:|...:....|.:||..::|:.::|||.|.:
Human    37 KRDDTKDTYKLPHRLIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTA 101

  Fly   120 ECQQK------------------ESD---YRSGYMDCMKEAAKFLYDVH----MQDFCHRLLGRL 159
            ..:|:                  :||   :.||:..|.||..::|....    .:..|.:|:..|
Human   102 LTEQQHQKIIALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHL 166

  Fly   160 QEHIDEMFKTDCYKSTRSCHMPDNVSASSGSPHQAYH-------------PPLCHLRDMLATSAS 211
            .....:...|   ....:..:|  :|..:|:|..|..             .||.:...::..:..
Human   167 HAVATQFLPT---PQLLTQQVP--LSKGTGAPSAAGSAAAPCLERAGQKLEPLAYCVPVIQRTQP 226

  Fly   212 DVEHSQDHNDVKDLSFRNHLNQLQRSQQAAAAAAV------------------------------ 246
            ..|.:.:::...|..:..........::...|.|.
Human   227 SAELAAENDTDTDSGYGGEAEARPDREKGKGAGASRVTIKQEPPGEDSPAPKRMKLDSRGGGSGG 291

  Fly   247 -----AAAAVAVANGSSPASNAGV---DSKV--PLTNGGGTGGAP---PAADNVP--------SN 290
                 ||||.|...|..||:.|.:   |:.:  .|...||.||||   |||...|        |.
Human   292 GPGGGAAAAAAALLGPDPAAAAALLRPDAALLSSLVAFGGGGGAPFPQPAAAAAPFCLPFCFLSP 356

  Fly   291 STGS---------------------------------GSAAACAGGNSNSSGSNSSNAASSTICP 322
            |..:                                 ..|||.|...:.::.:.:....||.:.|
Human   357 SAAAAYVQPFLDKSGLEKYLYPAAAAAPFPLLYPGIPAPAAAAAAAAAAAAAAAAFPCLSSVLSP 421

  Fly   323 PAGGSCPAKVTPLAAHQQPHQ-APVITSTAPHHHHHHTDSSHHDFESSREP 372
            |     |.|....||...||: ||:   .|||..|.| ..:|..|...|||
Human   422 P-----PEKAGAAAATLLPHEVAPL---GAPHPQHPH-GRTHLPFAGPREP 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cwo	NP_524775.1	HLH	66..118	CDD:306515	22/51 (43%)
		ORANGE	126..168	CDD:128787	11/48 (23%)
BHLHE41	NP_110389.1	bHLH-O_DEC2	31..122	CDD:381593	27/84 (32%)
		Necessary for interaction with RXRA and repressor activity towards RXRA. /evidence=ECO:0000269|PubMed:19786558	67..71		1/3 (33%)
		ORANGE	129..175	CDD:128787	9/45 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	228..298		4/69 (6%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	438..482		12/30 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140967
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740