DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cwo and helt

DIOPT Version :9

Sequence 1:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_996948.1	Gene:	helt / 404275	ZFINID:	ZDB-GENE-040824-6	Length:	270	Species:	Danio rerio

Alignment Length:	224	Identity:	60/224 - (26%)
Similarity:	102/224 - (45%)	Gaps:	49/224 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 KTSRQDPLSHRIIEKRRRDRMNSCLADLSRLIPPQYQRKGRGRIEKTEIIEMAIRHLKHLQS--- 119
            |..::.|:||::||||||||:|.||.:|.:.:|....::..|::||.||:||.:::|:.|.|
Zfish    55 KDRKKTPVSHKVIEKRRRDRINRCLNELGKTVPMALAKQNSGKLEKAEILEMTVQYLRALHSADF 119

  Fly   120 -------ECQQKESDY-RSGYMDCMKEAAKFLYDVHMQDF----CHRLLGRLQEHI--DEMF--- 167
                   |...:.::| ..||.:|||....:|..|...:.    ..|:|..||..:  :.:|
Zfish   120 PRGREKGELLTEFANYFHYGYHECMKNLVHYLTTVERMETKDTKYARILAFLQSKVVTEPVFGSL 184

  Fly   168 ------KTD--CYKSTRSCHMPDNVSASSGSPHQAYH-----PPLCHLRDMLATSASDVEHSQDH 219
                  .||  |....:|....::|...|...|.::|     |.|.:        .:..:||...
Zfish   185 GTISPDPTDLLCQLEYQSPSPTESVFQQSPPGHFSWHSSTRSPTLAY--------PAMSQHSGYL 241

  Fly   220 NDVKDLSFRNHLN-------QLQRSQQAA 241
            :.|:.|. .:::|       .|..:|.||
Zfish   242 SPVQGLD-HHYMNFIGHNAFSLHNAQHAA 269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cwo	NP_524775.1	HLH	66..118	CDD:306515	23/51 (45%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	13/57 (23%)
helt	NP_996948.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		HLH	62..115	CDD:278439	23/52 (44%)
		Hairy_orange	136..173	CDD:284859	10/36 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573827
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1054305at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850