DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cwo and Hes2

DIOPT Version :9

Sequence 1:	NP_524775.1	Gene:	cwo / 44669	FlyBaseID:	FBgn0259938	Length:	698	Species:	Drosophila melanogaster
Sequence 2:	NP_062109.1	Gene:	Hes2 / 29567	RGDID:	62082	Length:	157	Species:	Rattus norvegicus

Alignment Length:	142	Identity:	40/142 - (28%)
Similarity:	60/142 - (42%)	Gaps:	27/142 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 IIEKRRRDRMNSCLADLSRLIPPQY--QRKGRGRIEKTEIIEMAIRHLKH-----LQSECQQKES 126
            ::|||||.|:|..|:.|..|:.|..  :.....::||.:|:||.:|.|:.     ..:|......
  Rat    20 LLEKRRRARINESLSQLKGLVLPLLGAETSRYSKLEKADILEMTVRFLREQPASVCSTEAPGSLD 84

  Fly   127 DYRSGYMDCMKEAAKFLYDVHMQDFCHRL----LGRLQEHIDEMFKTDCYKSTRSCHMPDNVSAS 187
            .|..||..|:...|:.|      ..|..|    ..||.||:.:        .|.|...|....||
  Rat    85 SYLEGYRACLARLARVL------PACSVLEPAVSARLLEHLRQ--------RTVSGGPPSLTPAS 135

  Fly   188 SGSPHQAYHPPL 199
            :.:|  |..||:
  Rat   136 ASAP--APSPPV 145

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cwo	NP_524775.1	HLH	66..118	CDD:306515	18/55 (33%)
cwo	NP_524775.1	ORANGE	126..168	CDD:128787	12/45 (27%)
Hes2	NP_062109.1	HLH	12..69	CDD:238036	18/48 (38%)
		ORANGE	84..128	CDD:128787	14/57 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	124..157		8/24 (33%)
		WRPW motif	154..157
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4304
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740